Cimetidine induces hepatic heme oxygenase activity without altering hepatic heme catabolism

Experientia
J ReichenG Kirshenbaum

Abstract

Cimetidine inhibits oxidative drug metabolism; it is not known whether this drug alters the catabolic fate of hepatic heme. We therefore investigated hepatic heme turnover both by a 14CO breath test and directly by labeling the heme pool. Neither acute (150 mg/kg i.p.) nor chronic (150 mg/kg i.p. bid for 3 days) cimetidine administration significantly affected hepatic heme turnover. Chronic, but not acute, cimetidine significantly (p less than 0.025) increased heme oxygenase activity. Cimetidine inhibited heme oxygenase activity in vitro at concentrations achieved in vivo.

References

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Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M D Maines, A Kappas
May 1, 1983·The American Journal of Physiology·L ReussT P Grady
Aug 1, 1980·European Journal of Clinical Pharmacology·J PuurunenO Pelkonen
Nov 15, 1980·Biochemical Pharmacology·O Pelkonen, J Puurunen
Nov 1, 1957·Biochimica Et Biophysica Acta·R F LABBE, G NISHIDA

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Citations

Apr 15, 1988·Experientia·A L Jordi-RacineJ Reichen
Jan 15, 1989·Biochemical Pharmacology·R A Galbraith, P H Jellinck
Aug 15, 1989·Biochemical and Biophysical Research Communications·M LevineG D Bellward
Feb 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A W WrightP E Reilly

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