PMID: 6110040Feb 21, 1981Paper

Cimetidine is unlikely to increase formation of intragastric N-nitroso-compounds in patients taking a normal diet

Lancet
T J MuscroftM R Keighley

Abstract

Studies in fasting subjects have suggested that cimetidine therapy might lead to nocturnal hypochlorhydria, allowing bacterial overgrowth and the production of intragastric carcinogens. This hypothesis was investigated in normal subjects taking full-dose and maintenance cimetidine with food. Nocturnal hypochlorhydria wa rarely found and the incidence of bacterial overgrowth was correspondingly low; gastric-juice nitrite concentrations were rarely raised. These findings suggest that long term treatment with cimetidine is unlikely to promote gastric cancer as a result of bacterial metabolic activity.

References

Aug 1, 1978·The British Journal of Surgery·D GatehouseM R Keighley
Nov 1, 1979·World Journal of Surgery·J C Nicholls
Aug 1, 1980·American Journal of Surgery·L DomellöfJ H Weisburger
Aug 12, 1950·British Medical Journal·J MOSBECH, A VIDEBAEK

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Citations

Jan 1, 1983·Digestive Diseases and Sciences·G L Eastwood, G F Quimby
Jan 21, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hideyuki UbukataTakafumi Tabuchi
Mar 1, 1993·Baillière's Clinical Gastroenterology·R V Heatley, G M Sobala
Aug 15, 1981·Lancet·A H KiddG Hawkins
Aug 15, 1981·Lancet·B T BellanderB G Osterdahl
Dec 5, 1981·Lancet·M G HarringtonJ A Simpson
Dec 5, 1981·Lancet·P I ReedF R House
Jun 13, 1981·Lancet·J H Weisburger
Feb 13, 1982·Lancet·J B SaundersA Paton
Feb 13, 1982·Lancet·R W Brimblecomble
Dec 1, 1983·The New England Journal of Medicine·J B ZeldisK J Isselbacher
Nov 6, 1982·British Medical Journal·D G Colin-JonesM P Vessey
Jul 1, 1984·Postgraduate Medical Journal·J T BourneR E Barry
Apr 11, 1981·British Medical Journal
Aug 1, 1985·The British Journal of Surgery·C G ClarkT Gledhill
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·K G Wormsley
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·R W Stockbruegger
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·M J Langman
May 1, 1982·Infection and Immunity·R SneparD Kaye
Mar 1, 1986·American Journal of Surgery·H T Debas, M W Mulholland

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