Cimetidine potentiates the anticoagulant effect of warfarin by inhibition of drug metabolism

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Cimetidine potentiates the anticoagulant effect of warfarin by inhibition of drug metabolism

Abstract

References

Localization of histamine and histamine H2-receptor antagonists in the gastric mucosa.

Cimetidine: interaction with oral anticoagulants in man

A study of the effect of anticoagulants on [3H]vitamin K1 metabolism and prothrombin complex activity in the rabbit

Cimetidine inhibits microsomal drug metabolism in the rat

Phenobarbitone effects on hepatic microsomal enzymes and liver blood flow in the guinea pig.

Comparative pharmacokinetics of coumarin anticoagulants. X. Relationship between distribution, elimination, and anticoagulant action of warfarin

Kinetics of pharmacologic effects in man: the anticoagulant action of warfarin

Citations

Effect of cimetidine on the metabolism of cholephilic dyes in Gilbert's syndrome

Differential effects of cimetidine on theophylline metabolic pathways

Comparative pharmacokinetics and cardiovascular effects of tiapamil in healthy volunteers and patients with hepatic cirrhosis

Effects of cimetidine on drug metabolism in rat pups

The interaction of cimetidine with rat liver microsomes

Effects of maternally administered cimetidine during lactation on the development of drug metabolizing enzymes in mouse pups

The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity

Inhibitory effect of propylthiouracil-induced hypothyroidism in rat on oxidative drug metabolism

The actions of the H2-blocker cimetidine on the toxicity and biotransformation of the phosphorothioate insecticide parathion

The effect of preincubation with cimetidine on the N-hydroxylation of dapsone by human liver microsomes

The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes

Effect of cimetidine on phenytoin serum levels

Enzymatic shunting: resolving the acetaminophen-warfarin controversy

Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol

Cimetidine-drug interactions

Mechanisms of the inhibition of cytochrome P-450-mediated drug oxidation by therapeutic agents

Cimetidine: an inhibitor and an inducer of rat liver microsomal cytochrome P-450

Inhibition of tolbutamide metabolism by substituted imidazole drugs in vivo: evidence for a structure-activity relationship

Tolbutamide as a model drug for the study of enzyme induction and enzyme inhibition in the rat

Evidence for lipid involvement in the high-affinity interaction between cimetidine and rat liver cytochrome P-450

Cimetidine inhibition of theophylline elimination: the influence of adult age and the time course

Effects of working environment on the liver in 10 anaesthetists

Do all histamine2-antagonists cause a warfarin drug interaction?

Cimetidine as an inhibitor of drug metabolism: therapeutic implications and review of the literature

Comment: peptic ulcer H2-receptor antagonist therapy

Review of cimetidine drug interactions

The hepatic and renal mechanisms of drug interactions with cimetidine

The effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of metoprolol.

Cimetidine does not increase the anticoagulant effect of phenprocoumon

Lack of effect of ranitidine on warfarin action

Evaluation of monooxygenase induction as a means of enhancing the yield of the rat liver cytochrome P-450 isoenzyme with high affinity for cimetidine

Evidence for induction of hepatic microsomal cytochrome P-450 by cimetidine: binding and kinetic studies

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