PMID: 6106621Nov 1, 1980Paper

Cimetidine spares the glucuronidation of lorazepam and oxazepam

Gastroenterology
R PatwardhanK V Speeg

Abstract

Lorazepam (Ativan) disposition and elimination were studied in 8 normal subjects before and after 1 wk of cimetidine therapy, 300 mg taken orally four times a day. In 4 of these 8 normal subjects the disposition and elimination of oxazepam (Serax) were also studied before and after similar treatment with cimetidine. Cimetidine did not alter the elimination of either lorazepam or oxazepam. Since both drugs are eliminated exclusively after conjugation as glucuronide, this study demonstrates a relative sparing of this pathway of biotransformation of drugs in subjects receiving cimetidine.

Citations

Nov 1, 1980·European Journal of Clinical Pharmacology·U Klotz, I Reimann
Jan 1, 1991·Pharmacology & Therapeutics·J O Miners, P I Mackenzie
Dec 1, 1986·Toxicology Letters·J F Ghersi-EgeaC Saunier
Apr 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P DostertI Poggesi
Jan 1, 1993·Pharmacology & Toxicology·J Sonne
Feb 1, 1983·Postgraduate Medical Journal·F I LeeF T Costello

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