PMID: 11930101Apr 4, 2002Paper

Cimetropium bromide in the treatment of crisis in infantile colic

Journal of Pediatric Gastroenterology and Nutrition
F SavinoL Silvestro

Abstract

Treatment of infantile colic remains an open issue. In Italy, cimetropium bromide is used extensively to treat infantile colic. The aim of this randomized, double-blind, placebo-controlled clinical trial was to investigate the effectiveness and side effects of cimetropium bromide in the treatment of infants with colic crisis. Ninety-seven infants with colic were enrolled. The diagnosis of infantile colic in healthy infants with regular growth, aged 15 to 60 days was made according to the criteria of Wessel. The infants were divided into two groups, one treated with cimetropium bromide (1.2 mg/kg) and the other treated with placebo at onset of each crisis for 3 days. Duration of crying and side effects were recorded daily in a structured diary for the 3 days of therapy. Statistical analysis was performed using the chi-square and t tests. Eighty-six infants completed the trial. The average duration of crying for each crisis was 17.3 +/- 12.6 minutes in the cimetropium bromide group and 47.5 +/- 28.5 minutes in the placebo group (P < 0.005). Response to cimetropium bromide was 74%. Response to placebo was 33% (P < 0.05). Side effects did not differ significantly between the two groups, except sleepiness, which increased in the inf...Continue Reading

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Citations

Nov 9, 2004·Indian Journal of Pediatrics·Pankaj Garg
Sep 23, 2010·Current Opinion in Pediatrics·Francesco Savino, Valentina Tarasco
Apr 8, 2011·Journal of Paediatrics and Child Health·Belinda HallAnske Robinson
Nov 2, 2007·Public Health Nursing·Esra Karaca Ciftçi, Duygu Arikan
Feb 6, 2009·BMC Pediatrics·Kazeem A OshikoyaOlisamedua F Njokanma
Jul 25, 2012·Italian Journal of Pediatrics·Abdelmoneim E M Kheir
Jun 6, 2014·Italian Journal of Pediatrics·Francesco SavinoLuca Cordero di Montezemolo
Mar 1, 2012·La Presse médicale·Virginie Bruyas-BertholonLaurent Letrilliart
Nov 10, 2012·Nutrition·Yvan VandenplasPedro Alarcon
Aug 21, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ralf G Heine
Aug 28, 2007·Acta Paediatrica·Francesco Savino
Apr 26, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Mustafa Akçam, Aygen Yilmaz
Dec 4, 2014·Beneficial Microbes·Y Vandenplas, P Alarcon
Jul 18, 2016·Italian Journal of Pediatrics·Silvia SalvatoreUNKNOWN SIPPS Working Group on FGIDs
Sep 21, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M CamilleriA Staiano
Aug 11, 2004·The Journal of the Royal Society for the Promotion of Health·Alexander K C Leung, Jean François Lemay
Sep 16, 2016·The Cochrane Database of Systematic Reviews·Elena BiagioliFrancesco Savino
Jun 22, 2007·Phytotherapy Research : PTR·Raffaele CapassoFrancesco Capasso
Feb 3, 2018·Medicine·Pedro Gutiérrez-CastrellónGabriel López-Velázquez
May 4, 2006·Current Opinion in Allergy and Clinical Immunology·Ralf G Heine
Dec 4, 2019·The Cochrane Database of Systematic Reviews·Morris GordonShel Sc Banks

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