Cine magnetic resonance microscopy of the rat heart using cardiorespiratory-synchronous projection reconstruction

Journal of Magnetic Resonance Imaging : JMRI
Anja C S BrauG Allan Johnson

Abstract

To tailor a cardiac magnetic resonance (MR) microscopy technique for the rat that combines improvements in pulse sequence design and physiologic control to acquire high-resolution images of cardiac structure and function. Projection reconstruction (PR) was compared to conventional Cartesian techniques in point-spread function simulations and experimental studies to evaluate its artifact sensitivity. Female Sprague-Dawley rats were imaged at 2.0 T using PR with direct encoding of the free induction decay. Specialized physiologic support and monitoring equipment ensured consistency of biological motion and permitted synchronization of imaging with the cardiac and respiratory cycles. The reduced artifact sensitivity of PR offered improved delineation of cardiac and pulmonary structures. Ventilatory synchronization further increased the signal-to-noise ratio by reducing inter-view variability. High-quality short-axis and long-axis cine images of the rat heart were acquired with 10-msec temporal resolution and microscopic spatial resolution down to 175 microm x 175 microm x 1 mm. Integrating careful biological control with an optimized pulse sequence significantly limits both the source and impact of image artifacts. This work repre...Continue Reading

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Citations

Feb 4, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ben T ChenG Allan Johnson
Mar 2, 2006·Toxicologic Pathology·Cristian T BadeaG Allan Johnson
Feb 28, 2007·Toxicologic Pathology·Bastiaan Driehuys, Laurence W Hedlund
Sep 14, 2012·Physics in Medicine and Biology·Darin ClarkCristian T Badea
Jan 4, 2008·ILAR Journal·Bastiaan DriehuysLaurence W Hedlund
Dec 15, 2005·Proceedings of the American Thoracic Society·Laurence W Hedlund, G Allan Johnson
Mar 24, 2011·Future Medicinal Chemistry·Britto S SandanarajNicolau Beckmann
Apr 20, 2010·Journal of Pharmacological and Toxicological Methods·Cristian T BadeaG Allan Johnson
Jul 29, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Magdalena ZurekYannick Crémillieux
Mar 31, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Wilfried MaïG Allan Johnson
Sep 28, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bassem HibaMarc Janier
Oct 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hasan AlsaidEmmanuelle Canet-Soulas
Jun 27, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Elizabeth BucholzG Allan Johnson
Feb 8, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bassem HibaPierre Croisille

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