Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: Beyond the breath-hold

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
A KhalafC L Hoad

Abstract

The symptoms of functional bowel disorders are common in postprandial but investigations are generally undertaken in the fasted state using invasive procedures. MRI provides a noninvasive tool to study the gastrointestinal tract in an unperturbed, fed state. The aim of this study was to develop a technique to assess small bowel motility from cine MRI data in the unprepared bowel in fasting and fed states. Fifteen healthy volunteers underwent a baseline MRI scan after which they consumed a 400 g soup. Subjects then underwent a postprandial scan followed by further scans at regular intervals. Small bowel motility was assessed using single-slice bTFE cine MRI. An optimized processing technique was used to generate motility data based on power spectrum analysis of voxel-signal changes with time. Interobserver variability (n = 15) and intra-observer (n = 6) variability were assessed. Changes in the motility index were compared between fasted and immediate postprandial state. Excellent agreement between observers was seen across the range of motility measurements acquired, with intraclass correlation coefficient (ICC) of 0.979 (P < 0.0001) and Bland-Altman limits of agreement 95% CI: -28.9 to 45.9 au. Intra-observer variability was l...Continue Reading

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Citations

May 29, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Robin Spiller, Caroline Hoad
Jan 13, 2021·Physiological Measurement·Elisabeth K SteinsvikOdd Helge Gilja
Dec 20, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Neele S DellschaftAlan R Smyth

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