PMID: 6405412Feb 1, 1983Paper

Cingulate lesions and behavioral adaptation to amino acid imbalanced diets

Physiology & Behavior
L L MelizaQ R Rogers

Abstract

The effect of anterior cingulate cortex lesions on dietary intake and adaptation of disproportionate amounts of amino acids was examined. Rats with bilateral electrolytic lesions in the anterior cingulate cortex and sham-operated rats were fed, in turn, amino acid basal, imbalanced or devoid diets involving threonine and isoleucine as the growth limiting amino acids, and then a low protein (6% casein) followed by a high protein (75% casein) diet. Lesions of the anterior cingulate cortex did not prevent the initial depression in food intake of the amino acid imbalanced diets, but shortened the duration of anorexia associated with dietary amino acid imbalances. Cingulate lesions did not influence the food intake of rats fed amino acid devoid diets. When switched from a low protein to a high protein diet, animals bearing lesions and sham-operated controls reduced markedly their initial food intake and adapted to the high protein diet in similar manner. It was concluded that the initial food intake depression associated with a dietary amino acid imbalance is a direct response to postingestive cues which influence food intake. Moreover, that the difference in adaptive intakes of the cingulate cortex lesioned animals who ingested a d...Continue Reading

References

Jan 1, 1979·The British Journal of Nutrition·G Tobin, K N Boorman
Jul 1, 1976·Journal of Comparative and Physiological Psychology·R V KraneG J Thomas
Jul 1, 1974·Pharmacology, Biochemistry, and Behavior·P C Simson, D A Booth
Oct 1, 1972·Psychological Bulletin·P A Fried
Dec 1, 1972·Behavioral Biology·B K McGowanJ Garcia
May 1, 1973·Journal of Comparative and Physiological Psychology·B J Rolls, E T Rolls
Jan 15, 1969·Life Sciences·P M Leung, Q R Rogers

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