Cinnabar induces renal inflammation and fibrogenesis in rats

BioMed Research International
Ying WangHonglin Ma

Abstract

The purpose of this study was to investigate whether cinnabar causes renal inflammation and fibrosis in rats. Rats were dosed orally with cinnabar (1 g/kg/day) for 8 weeks or 12 weeks. The control rats were treated with solvent (5% carboxymethylcellulose solution) over the same time periods, respectively. Renal mercury (RHg), urinary mercury (UHg), serum creatinine (SCr), urine kidney injury molecule 1 (KIM-1), renal pathology, and renal mediators were examined. At both 8 weeks and 12 weeks, RHg, UHg, and urine KIM-1 were significantly higher in the cinnabar group than in the control group, although SCr was unchanged. Kidney lesions in the cinnabar-treated rats occurred mainly in the tubules and interstitium, including vacuolization, protein casts, infiltration of inflammatory cells, and slight increase in interstitial collagen. In addition, mild mesangial proliferation was observed in glomeruli. Moreover, the expression of inflammatory and fibrogenic mediators was upregulated in the cinnabar group. In conclusion, cinnabar may cause kidney damage due to the accumulation of mercury, and renal inflammation and slight fibrogenesis may occur in rats. In the clinic, the potential risk of renal injury due to the prolonged consumption...Continue Reading

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Citations

Nov 12, 2018·Journal of Integrative Plant Biology·Pan LiXin-Guang Zhu
May 29, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tianjiao ForestoTae-Hong Lim
Nov 13, 2020·Frontiers in Pharmacology·Xiaofen XuKuilong Wang

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Methods Mentioned

BETA
atomic fluorescence spectrometry
atomic absorption spectrometry
ELISA
antibody array
light microscopy

Software Mentioned

RayBio

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