Cinnamaldehyde reduction of platelet aggregation and thrombosis in rodents.

Thrombosis Research
Jingqun HuangXinyou Shi

Abstract

Cinnamaldehyde (CA) has been reported to inhibit in vitro aggregation in human and rabbit platelets; however, little is known about the antithrombotic activities of CA in vivo. We tested the effects of CA on collagen- or thrombin-induced aggregation of rat platelets in vitro. Hemorrhage and coagulation times of mice treated with CA by the tail-cutting or slide method were measured. We also tested the life-saving effects of CA on experimental models of thrombosis in mice and rats. The anti-platelet effects of CA were examined in rats. CA inhibited collagen- and thrombin-induced platelet aggregation in vitro in a concentration-dependent manner. In mice, CA administration (250, 500 mg/kg orally and 50, 100 mg/kg i.p.) markedly prolonged hemorrhage and coagulation times and effectively reduced the mortality rate of collagen-epinephrine-induced acute pulmonary thromboembolism. In an arteriovenous shunt thrombosis rat model, the CA administration (250, 500 mg/kg orally and 50, 100 mg/kg i.p.) for 10 days dose-dependently decreased thrombus weight. Administration of CA also significantly inhibited collagen-induced platelet aggregation in the rat platelet-rich plasma (PRP). The results demonstrate that CA may be a promising antithrombo...Continue Reading

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Citations

May 24, 2011·Vascular Health and Risk Management·Yong-Liang XueKa Bian
Dec 3, 2013·Journal of Pharmaceutical and Biomedical Analysis·Hang ZhaoSiwang Wang
May 13, 2010·The American Journal of the Medical Sciences·YuanYuan DingSiwang Wang
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Jun 9, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R H Raghavendra, K Akhilender Naidu
Jun 24, 2008·Thrombosis Research·Yao-Zu XiangBo-Li Zhang
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Aug 11, 2016·Restorative Dentistry & Endodontics·Dokyung KimSung Kyo Kim
Jan 3, 2013·Evolutionary Anthropology·Matt Cartmill
Nov 22, 2019·The Journal of Pharmacy and Pharmacology·Jia LiuXu-Feng Pu

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