Cinnamamide: An insight into the pharmacological advances and structure-activity relationships

European Journal of Medicinal Chemistry
Nikhil GaikwadY V Madhavi

Abstract

The cinnamamide (cinnamic acid amide and cinnamide) is a privileged scaffold present widely in a number of natural products. The scaffold acts as a useful template for designing and arriving at newly drug-like molecules with potential pharmacological activity. An attempt has been made to review the extensive occurrence of cinnamamide scaffold in many lead compounds reported for treating various diseases, their binding interactions with the therapeutic targets as well as mechanism of action and their structure-activity relationships. The discoveries of cinnamamide systems and some examples of unusual cinnamamides having an aromatic, aliphatic, and heterocyclic or other rings condensed to the basic cinnamamide structure also have been extensively covered in this review.

Citations

Sep 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiri KosJosef Jampilek
Aug 14, 2020·International Journal of Molecular Sciences·Ngonidzashe Ruwizhi, Blessing Atim Aderibigbe
Dec 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan HošekJosef Jampílek
Jan 19, 2021·Natural Product Research·Ahmed OthmanKuniyoshi Shimizu
Jan 19, 2021·Critical Reviews in Food Science and Nutrition·Zhiyun PengYong Zhao

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