Cinnamic acid exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Rahman M HafizurRehan A Siddiqui

Abstract

Although the anti-diabetic activity of cinnamic acid, a pure compound from cinnamon, has been reported but its mechanism(s) is not yet clear. The present study was designed to explore the possible mechanism(s) of anti-diabetic activity of cinnamic acid in in vitro and in vivo non-obese type 2 diabetic rats. Non-obese type 2 diabetes was developed by injecting 90 mg/kg streptozotocin in 2-day-old Wistar pups. Cinnamic acid and cinnamaldehyde were administered orally to diabetic rats for assessing acute blood glucose lowering effect and improvement of glucose tolerance. Additionally, insulin secretory activity of cinnamic acid and cinnamaldehyde was evaluated in isolated mice islets. Cinnamic acid, but not cinnamaldehyde, decreased blood glucose levels in diabetic rats in a time- and dose-dependent manner. Oral administration of cinnamic acid with 5 and 10 mg/kg doses to diabetic rats improved glucose tolerance in a dose-dependent manner. The improvement by 10 mg/kg cinnamic acid was comparable to that of standard drug glibenclamide (5 mg/kg). Further in vitro studies showed that cinnamaldehyde has little or no effect on glucose-stimulated insulin secretion; however, cinnamic acid significantly enhanced glucose-stimulated insulin...Continue Reading

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Citations

Dec 5, 2015·Phytotherapy Research : PTR·Ramachandran VinayagamBaojun Xu
Jan 29, 2016·International Journal of Biological Macromolecules·Zihao Wei, Yanxiang Gao
Jan 19, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Arrigo F G Cicero, Alessandro Colletti
Nov 6, 2018·Environmental Science and Pollution Research International·Ahmed AbdeenMohamed Abdel-Daim
Jan 22, 2019·Organic & Biomolecular Chemistry·Mohammad Nur-E-AlamAdnan J Al-Rehaily
Aug 29, 2019·Critical Reviews in Food Science and Nutrition·Anurag Khatkar, Krishna Kant Sharma
Oct 21, 2018·Reproductive Biology and Endocrinology : RB&E·Lei DouYi Guo
Feb 21, 2019·Experimental and Therapeutic Medicine·Meihua Zhou, Hongfeng Sui
Oct 4, 2017·Nutrition Reviews·Kaiyuan Yang, Catherine B Chan
May 3, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Ali Asghar HemmatiAkram Ahangarpour
Apr 23, 2017·BMC Complementary and Alternative Medicine·Rahman M HafizurNoor Fatima
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Sep 7, 2018·Frontiers in Pharmacology·Aminu Mohammed, Md Shahidul Islam
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Sep 9, 2021·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Syed Ali Raza ShahM Rahman Hafizur
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenyang WeiYu He

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