Cinnamic aldehyde inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in Zucker Diabetic Fatty rats.

Redox Biology
Nicholas E BuglakEdward S M Bahnson

Abstract

Atherosclerosis remains the number one cause of death and disability worldwide. Atherosclerosis is treated by revascularization procedures to restore blood flow to distal tissue, but these procedures often fail due to restenosis secondary to neointimal hyperplasia. Diabetes mellitus is a metabolic disorder that accelerates both atherosclerosis development and onset of restenosis. Strategies to inhibit restenosis aim at reducing neointimal hyperplasia by inhibiting vascular smooth muscle cell (VSMC) proliferation and migration. Since increased production of reactive oxygen species promotes VSMC proliferation and migration, redox intervention to maintain vascular wall redox homeostasis holds the potential to inhibit arterial restenosis. Cinnamic aldehyde (CA) is an electrophilic Nrf2 activator that has shown therapeutic promise in diabetic rodent models. Nrf2 is a transcription factor that regulates the antioxidant response. Therefore, we hypothesized that CA would activate Nrf2 and would inhibit neointimal hyperplasia after carotid artery balloon injury in the Zucker Diabetic Fatty (ZDF) rat. In primary ZDF VSMC, CA inhibited cell growth by MTT with an EC50 of 118 ± 7 μM. At a therapeutic dose of 100 μM, CA inhibited proliferati...Continue Reading

Citations

Dec 21, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Zheng YangMin Qiu
Feb 14, 2020·Cardiovascular Research·Nicholas E BuglakEdward S M Bahnson
Jan 11, 2020·Frontiers in Microbiology·Su QuJun Tian
Nov 19, 2019·Journal of Cellular and Molecular Medicine·Jing ZhangHong Jiang
Mar 1, 2021·Biochemical and Biophysical Research Communications·Xuebin WangChangwei Liu

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Methods Mentioned

BETA
scraping
nuclear translocation
nuclear
confocal microscopy

Software Mentioned

ImageJ
Nikon Elements
Muse Cell Analyzer
Gen
OriginLab

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