PMID: 11342256May 9, 2001Paper

Cinnamophilin as a novel antiperoxidative cytoprotectant and free radical scavenger

Biochimica Et Biophysica Acta
G HsiaoM H Yen

Abstract

The antioxidant properties of cinnamophilin were evaluated by studying its ability to react with relevant reactive oxygen species, and its protective effect on cultured cells and biomacromolecules under oxidative stress. Cinnamophilin concentration-dependently suppressed non-enzymatic iron-induced lipid peroxidation in rat brain homogenates with an IC50 value of 8.0+/-0.7 microM and iron ion/ADP/ascorbate-initiated rat liver mitochondrial lipid peroxidation with an IC50 value of 17.7+/-0.2 microM. It also exerted an inhibitory activity on NADPH-dependent microsomal lipid peroxidation with an IC50 value of 3.4+/-0.1 microM without affecting microsomal electron transport of NADPH-cytochrome P-450 reductase. Both 1,1-diphenyl-2-picrylhydrazyl and 2,2'-azo-bis(2-amidinopropane) dihydrochloride-derived peroxyl radical tests demonstrated that cinnamophilin possessed marked free radical scavenging capacity. Cinnamophilin significantly protected cultured rat aortic smooth muscle cells (A7r5) against alloxan/iron ion/H2O2-induced damage resulting in cytoplasmic membranous disturbance and mitochondrial potential decay. By the way, cinnamophilin inhibited copper-catalyzed oxidation of human low-density lipoprotein, as measured by fluoresc...Continue Reading

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Citations

Jul 27, 2005·Free Radical Biology & Medicine·E-Jian LeeTian-Shung Wu
Feb 18, 2012·Pakistan Journal of Biological Sciences : PJBS·Maryam Jafar SameriSeyed Mohammad Taghi Mansouri
Apr 5, 2005·Brain Research·Myeung Ju KimDong Hoon Shin
Apr 21, 2006·Asian Journal of Andrology·Jun-Fu ZhouShu-Mei Zhang
May 27, 2005·Journal of Biomedical Science·Shinn-Long LinMao-Hsiung Yen
Apr 30, 2005·Nutrition and Cancer·Amy L Webb, Marjorie L McCullough
Jan 1, 2005·Pharmaceutical Biology·Tülay Çoban, Belma Konuklugil
Jul 17, 2020·International Journal of Molecular Sciences·Thanasekaran JayakumarJoen-Rong Sheu

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