CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy.

Circulation Research
Zhan-Peng HuangDa-Zhi Wang

Abstract

Mammalian heart has minimal regenerative capacity. In response to mechanical or pathological stress, the heart undergoes cardiac remodeling. Pressure and volume overload in the heart cause increased size (hypertrophic growth) of cardiomyocytes. Whereas the regulatory pathways that activate cardiac hypertrophy have been well-established, the molecular events that inhibit or repress cardiac hypertrophy are less known. To identify and investigate novel regulators that modulate cardiac hypertrophy. Here, we report the identification, characterization, and functional examination of a novel cardiac Isl1-interacting protein (CIP). CIP was identified from a bioinformatic search for novel cardiac-expressed genes in mouse embryonic hearts. CIP encodes a nuclear protein without recognizable motifs. Northern blotting, in situ hybridization, and reporter gene tracing demonstrated that CIP is highly expressed in cardiomyocytes of developing and adult hearts. Yeast two-hybrid screening identified Isl1, a LIM/homeodomain transcription factor essential for the specification of cardiac progenitor cells in the second heart field, as a cofactor of CIP. CIP directly interacted with Isl1, and we mapped the domains of these two proteins, which mediat...Continue Reading

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Citations

Oct 6, 2015·The Journal of Clinical Investigation·Zhan-Peng HuangDa-Zhi Wang
Oct 8, 2016·Cellular and Molecular Life Sciences : CMLS·Zaffar K Haque, Da-Zhi Wang
Dec 7, 2013·Circulation Research·Kyung U Hong, Joseph B Moore
Jul 29, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jianming LiuDa-Zhi Wang
Mar 8, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Youchen YanZhan-Peng Huang
Sep 18, 2020·Nature Communications·Haipeng GuoDa-Zhi Wang
Jul 10, 2021·Experimental Cell Research·Yuting YangJuxiang Li
Aug 18, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xin HeDa-Zhi Wang
Dec 23, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Liat Salzer-SheeloLina Basel-Salmon

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