Ciprofloxacin for BK viremia prophylaxis in kidney transplant recipients: Results of a prospective, double-blind, randomized, placebo-controlled trial

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
S J PatelAhmed Osama Gaber

Abstract

In kidney transplantation, BK virus infection has historically resulted in high rates of graft dysfunction and graft loss. Unlike other opportunistic infections, no therapies have been shown to prevent BK. The purpose of the current study was to evaluate the safety and efficacy of ciprofloxacin for the prevention of BK viremia in kidney transplant recipients. Two hundred kidney transplant recipients were enrolled in a prospective, randomized, double-blind, placebo-controlled trial comparing a 3-month course of ciprofloxacin (n = 133) vs placebo (n = 67) for the prevention of BK viremia. The primary endpoint of BK viremia at month 6 posttransplant occurred in 25 (18.8%) patients in the ciprofloxacin group and 5 (7.5%) in the placebo group (P = .03). Higher rates of BK viremia (23.3% vs 11.9%; P = .06) and BK nephropathy (5.8% vs 1.5%; P = .26) remained at 12 months in the ciprofloxacin group. Ciprofloxacin use was associated with a significantly higher rate of fluoroquinolone-resistant gram-negative infections (83.3% vs 50%; P = .04). A 3-month course of ciprofloxacin was ineffective at preventing BK viremia in kidney transplant recipients and was associated with an increased risk of fluoroquinolone-resistant infections. Clinica...Continue Reading

Associated Clinical Trials

Feb 12, 2013·Ahmed Osama Gaber, MDAhmed Osama Gaber, MD

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Citations

Aug 4, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Yusuke ItoMineo Kurokawa
Mar 18, 2021·Reviews in Medical Virology·Zongsong WuHans H Hirsch
May 31, 2019·Current Opinion in Organ Transplantation·Jonathan Hand, Gopi Patel

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