Ciprofloxacin pharmacokinetics in dogs following oral administration

Zentralblatt für Veterinärmedizin. Reihe A
A R AbadíaM A Bregante

Abstract

This paper reports the variation of the pharmacokinetic parameters of ciprofloxacin (CIP) following oral administration of three single doses (10, 20 and 40 mg/kg body weight (b.w.)) to dogs. Plasma and urine samples were assayed by HPLC. The plasma vs. time data were submitted to classical compartmental kinetic analysis (one-compartment open model with a lag time) and to non-compartmental data analysis. The maximal plasma concentrations attained after administration of 10 and 20 mg/kg were 1.55 and 3.08 mg/l, respectively, and agree with results reported in the literature for this species. The absorption was slower and showed a longer and more variable lag time when the dose increased. The elimination rate was significantly smaller after administration of the 40 mg/kg (0.0014/min) than 10 and 20 mg/kg doses (near 0.0024/min). AUC/D also showed significant differences. The non-linearity of CIP pharmacokinetics after oral administration was demonstrated by fitting the data AUC vs. dose to a quadratic equation.

References

Jan 1, 1990·Antimicrobial Agents and Chemotherapy·K ShibaT Ooie
Mar 28, 1987·Lancet·B Salh, A K Webb
Jul 1, 1985·Antimicrobial Agents and Chemotherapy·R L DavisA L Smith
May 1, 1986·The Journal of Antimicrobial Chemotherapy·A S BayerK S Kim
Jan 1, 1986·Antimicrobial Agents and Chemotherapy·T A TartaglioneT M Kerkering
Nov 1, 1986·The Journal of Antimicrobial Chemotherapy·C J HackbarthM A Sande
Jan 29, 1988·The Medical Letter on Drugs and Therapeutics
Jun 1, 1987·Antimicrobial Agents and Chemotherapy·K I PlaisanceH C Standiford
Sep 1, 1987·Biopharmaceutics & Drug Disposition·M A HussainE Shefter
Jan 1, 1983·The Journal of Pharmacy and Pharmacology·K YamaokaT Uno
Nov 1, 1984·Antimicrobial Agents and Chemotherapy·M A GonzalezB Painter
Feb 1, 1984·Computer Programs in Biomedicine·S A Werness, D J Anderson
Oct 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·A R AbadíaM A Bregante

❮ Previous
Next ❯

Citations

Sep 4, 2009·Veterinary Research Communications·Faqir MuhammadM Javed Arshed
Jun 17, 2000·International Journal of Antimicrobial Agents·H García OvandoC Errecalde
Sep 11, 2007·Biosensors & Bioelectronics·Rodica E IonescuClaude Martelet
Jun 11, 2004·Journal of Veterinary Pharmacology and Therapeutics·G A AlbarellosM F Landoni
Jun 10, 2015·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Lorraine BarbosaFrances Gulland
Oct 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Louis M HuneaultCyril Désévaux
Jan 1, 2007·Journal of Robotic Surgery·N G HocksteinD J Terris
Oct 31, 2012·American Journal of Veterinary Research·Cristina López CadenasJuan J García Vieitez
Jun 29, 2012·American Journal of Veterinary Research·Mark G Papich
Aug 5, 2017·Journal of Veterinary Internal Medicine·M G Papich
Oct 17, 2020·Journal of the American Veterinary Medical Association·Erin Frey, Megan Jacob

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Veterinary Pharmacology and Therapeutics
A R AbadíaM A Bregante
Journal of Veterinary Pharmacology and Therapeutics
P M DowlingS H Duran
International Journal of Antimicrobial Agents
H García OvandoC Errecalde
© 2021 Meta ULC. All rights reserved