Circ-SATB2 upregulates STIM1 expression and regulates vascular smooth muscle cell proliferation and differentiation through miR-939

Biochemical and Biophysical Research Communications
Yan-Yang MaoCong-Xia Wang

Abstract

The prevention and treatment of coronary heart disease (CHD) is a difficult problem to be solved. More and more studies have found that circular RNAs (circRNAs) may play important roles in the development of CHD. Here detection of vascular smooth muscle cells (VSMCs) showed that circ-SATB2 and STIM1 were up-regulated in proliferative VSMCs, while miR-939 were down-regulated. Circ-SATB2 and miR-939 did not affect the expression of each other, but circ-SATB2 could promote while miR-939 inhibited the expression of STIM1 (a target gene of miR-939). Circ-SATB2 overexpression could inhibit the expression of SM22-alpha (SM22α, a marker of contractile VSMCs), while the expression of SM22α was promoted by miR-939. STIM1 could promote cell proliferation and migration, and circ-SATB2 had similar effects, but its linear sequence had no such functions. MiR-939 had the opposite effects, could promote cell apoptosis and inhibit cell proliferation and migration, and siRNAs targeting circ-SATB2 had similar effects. When co-transfected with circ-SATB2 over-expression vector and miR-939 mimics or STIM1 siRNAs, the changes of cell proliferation, apoptosis and migration were not significant. Therefore, circ-SATB2 can regulate VSMC phenotypic differ...Continue Reading

Citations

Sep 29, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ji-Ru Zhang, Hai-Jian Sun
Mar 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Fei LinChao Liu
Dec 23, 2020·Journal of Cellular and Molecular Medicine·Ying TangDan-Yan Xu
Nov 16, 2020·Life Sciences·Yuchan YuanPeng Qu
Dec 17, 2020·International Journal of Cardiology·Shuna HuangSiying Wu
Mar 6, 2021·Molecular Therapy. Nucleic Acids·Xi YangYonghong Li
Mar 13, 2021·Frontiers in Cardiovascular Medicine·Soudeh Ghafouri-FardMohammad Taheri
May 26, 2020·Life Sciences·Qidong CaoChunli Song
Jul 27, 2021·Oxidative Medicine and Cellular Longevity·Yanshuo HanJian Zhang
Jul 17, 2021·Cardiovascular Drugs and Therapy·Kai WangLu-Yu Zhou
Jul 25, 2021·Vascular Pharmacology·Xueyuan SunLijuan Huang
Aug 28, 2021·International Journal of Molecular Sciences·Yaping WangXiaoyong Tong
Dec 23, 2021·Cellular and Molecular Life Sciences : CMLS·Feng ZhangLing Mao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.