Circ2Disease: a manually curated database of experimentally validated circRNAs in human disease

Scientific Reports
Dongxia YaoPengyuan Liu

Abstract

Circular RNAs (circRNAs), a new class of regulatory noncoding RNAs, play important roles in human diseases. While a growing number of circRNAs have been characterized with biological functions, it is necessary to integrate all the information to facilitate studies on circRNA functions and regulatory networks in human diseases. Circ2Disease database contains 273 manually curated associations between 237 circRNAs and 54 human diseases with strong experimental evidence from 120 studies. Each association includes circRNA name, disease name, expression pattern, experimental method, a brief functional description of the circRNA-disease relationship, and other detailed information. The experimentally validated miRNAs that may be 'sponged up' by these circRNAs and their validated targets were also integrated to form a comprehensive regulatory network. Circ2Disease provides a user-friendly interface to browse, search, analyze regulatory network and download data. With the rapidly increasing interest in circRNAs, Circ2Disease will significantly improve our understanding of circRNA deregulation in diseases and is a useful resource for studying posttranscriptional regulatory roles of circRNAs in human diseases.

References

Jan 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C CocquerelleB Bailleul
Apr 8, 1999·Molecular Pathology : MP·J A DuncanT G Cooke
Nov 11, 2008·Nucleic Acids Research·Feifei XiaoTongbin Li
Dec 20, 2012·RNA·William R JeckNorman E Sharpless
Mar 1, 2013·Nature·Thomas B HansenJørgen Kjems
Mar 1, 2013·Nature·Sebastian MemczakNikolaus Rajewsky
Sep 17, 2013·Molecular Cell·Yang ZhangLing-Ling Chen
Sep 17, 2013·PLoS Genetics·Julia SalzmanPatrick O Brown
Dec 18, 2013·Frontiers in Genetics·Suman GhosalJayprokas Chakrabarti
Sep 23, 2014·RNA·Petar GlažarNikolaus Rajewsky
Nov 8, 2014·Clinical Chemistry·Jae Hoon BahnXinshu Xiao
Dec 19, 2014·BMC Cancer·Chirayu Pankaj Goswami, Harikrishna Nakshatri
Feb 11, 2015·Nature Structural & Molecular Biology·Zhaoyong LiGe Shan
Aug 13, 2015·ELife·Vikram AgarwalDavid P Bartel
Sep 30, 2015·Bioinformatics·Max FranzGary D Bader
Oct 10, 2015·Nucleic Acids Research·Yu-Chen LiuHsien-Da Huang
Feb 26, 2016·Nature Reviews. Molecular Cell Biology·Ling-Ling Chen
Aug 21, 2016·Briefings in Bioinformatics·Siyu XiaChunjiang He
Dec 3, 2016·Nucleic Acids Research·Zhen YangAndrew E Teschendorff
Oct 17, 2017·Nucleic Acids Research·Siyu XiaChunjiang He
Nov 11, 2017·Nucleic Acids Research·Chih-Hung ChouHsien-Da Huang
Feb 6, 2018·Molecular Metabolism·Lisa StollRomano Regazzi

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Citations

Apr 28, 2019·Journal of Biomedical Science·Chun-Ying Yu, Hung-Chih Kuo
Jan 31, 2020·Briefings in Bioinformatics·Marieke VrommanPieter-Jan Volders
May 19, 2020·PLoS Computational Biology·Kai ZhengYu-An Huang
Aug 25, 2020·Nucleic Acids Research·Lin NingDong Wang
Nov 6, 2018·International Journal of Molecular Sciences·Xiujuan LeiFang-Xiang Wu
Mar 29, 2020·Database : the Journal of Biological Databases and Curation·Mercy RophinaVinod Scaria
Apr 4, 2020·BMC Medical Genomics·Menglu LiJunfeng Xia
Jun 15, 2019·Briefings in Bioinformatics·Hang Wei, Bin Liu
Jan 8, 2020·International Journal of Molecular Sciences·Giulio FerreroMarco Beccuti
Feb 28, 2020·Briefings in Bioinformatics·Liang ChenGarry Wong
Nov 13, 2020·Database : the Journal of Biological Databases and Curation·Wei LanYi-Ping Phoebe Chen
Feb 9, 2021·Briefings in Functional Genomics·Yulian DingFang-Xiang Wu
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Sabah NisarMohammad Haris
Mar 7, 2021·Non-coding RNA·Elena López-Jiménez, Eduardo Andrés-León
Mar 10, 2021·Genome Biology·Huihui LiHongwei Wang
Apr 1, 2021·Briefings in Functional Genomics·Harpreet KaurGajendra P S Raghava
Mar 31, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ebrahim MahmoudiMurray J Cairns
Jun 10, 2021·BMC Bioinformatics·Zong-Lan ZuoChun-Hou Zheng
Oct 17, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jason R Brown, Arul M Chinnaiyan
Jun 4, 2021·Molecular Oncology·Barbara MonticoElisabetta Fratta
Jul 31, 2021·Briefings in Bioinformatics·Chun-Chun WangXing Chen
Nov 5, 2019·Molecular Aspects of Medicine·Jianhong LiuXiao Zhu
Nov 21, 2020·Journal of Biomedical Informatics·Guanghui LiHailin Chen

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Methods Mentioned

BETA
RNA-seq

Software Mentioned

Arraystar
circRNADb
circRNA
TargetScan
Circ2Disease
circNet
TAM
miRNA
CircInteractome
miRanda

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