Circadian 5-HT production regulated by adrenergic signaling

Proceedings of the National Academy of Sciences of the United States of America
Xing SunJimo Borjigin

Abstract

Using on-line microdialysis, we have characterized in vivo dynamics of pineal 5-hydroxytryptamine (5-HT; serotonin) release. Daily pineal 5-HT output is triphasic: (i) 5-HT levels are constant and high during the day; (ii) early in the night, there is a novel sharp rise in 5-HT synthesis and release, which precedes the nocturnal rise in melatonin synthesis; and (iii) late in the night, levels are low. This triphasic 5-HT production persists in constant darkness and is influenced strongly by intrusion of light at night. We demonstrate that both diurnal 5-HT synthesis and 5-HT release are activated by sympathetic innervation from the superior cervical ganglion and show that these processes are controlled by distinct receptors. The increase in 5-HT synthesis is controlled by beta-adrenergic receptors, whereas the increase in 5-HT release is mediated by alpha-adrenergic signaling. On the other hand, the marked decrease in 5-HT content and release late at night is a passive process, influenced by the extent of melatonin synthesis. In the absence of melatonin synthesis, the late-night decline in 5-HT release is prevented, reaching levels roughly twice as high as that of the day value. In summary, our results demonstrate that 5-HT lev...Continue Reading

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Citations

Dec 18, 2009·European Archives of Psychiatry and Clinical Neuroscience·Shadab Ataur RahmanColin Michael Shapiro
Jul 24, 2013·Neurochemical Research·Adam PrzybyłkowskiAndrzej Członkowski
Dec 22, 2009·Reviews in Endocrine & Metabolic Disorders·Asamanja ChattorajJimo Borjigin
Jun 14, 2005·General and Comparative Endocrinology·Rosa M CeinosJesús M Míguez
Apr 26, 2013·ACS Chemical Neuroscience·Hongyan YangAnne M Andrews
Sep 29, 2006·Journal of Circadian Rhythms·Tiecheng Liu, Jimo Borjigin
Dec 17, 2014·The Journal of Physiology·Haijie YuBertil Hille
Apr 17, 2013·Respiratory Physiology & Neurobiology·Jason H Mateika, Ziauddin Syed
Jul 26, 2011·Molecular and Cellular Endocrinology·Jimo BorjiginAnda-Alexandra Calinescu
Nov 30, 2007·Pharmacology, Biochemistry, and Behavior·Jimo Borjigin, Tiecheng Liu
Jun 28, 2005·Journal of Pineal Research·Neslihan B TutuncuTomris Erbas
Jun 28, 2005·Journal of Pineal Research·Tiecheng Liu, Jimo Borjigin
Jul 31, 2003·Journal of Pineal Research·Xing SunJimo Borjigin
Jan 21, 2009·Basic & Clinical Pharmacology & Toxicology·Soledad Sánchez MateosAna B Rodríguez
Jul 30, 2011·Journal of Neurochemistry·Louise RovsingDavid C Klein
Mar 15, 2011·The European Journal of Neuroscience·Stephanie Z YoungAngélique Bordey
Apr 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mellar P DavisSusan B LeGrand
Nov 4, 2005·Journal of Biological Rhythms·Tiecheng Liu, Jimo Borjigin
Nov 4, 2005·Journal of Biological Rhythms·Tiecheng Liu, Jimo Borjigin
Jul 1, 2013·Expert Review of Endocrinology & Metabolism·Mounir OuzirNouria Lakhdar-Ghazal
Feb 26, 2003·The Journal of Biological Chemistry·Jimo BorjiginMichael M Wang
Jun 20, 2008·Molecular and Cellular Biochemistry·Soledad SánchezCarmen Barriga
Jan 9, 2019·Frontiers in Neurology·Benton S PurnellGordon F Buchanan

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