Circadian and pharmacological regulation of casein kinase I in the hamster suprachiasmatic nucleus.

Journal of Genetics
Patricia V AgostinoDiego A Golombek

Abstract

In mammals, the mechanism for the generation of circadian rhythms and entrainment by light-dark (LD) cycles resides in the hypothalamic suprachiasmatic nuclei (SCN), and the principal signal that adjusts this biological clock with environmental timing is the light:dark cycle. Within the SCN, rhythms are generated by a complex of molecular feedback loops that regulate the transcription of clock genes, including per and cry. Posttranslational modification plays an essential role in the regulation of biological rhythms; in particular, clock gene phosphorylation by casein kinase I , both epsilon (CKIepsilon) and delta (CKIdelta), regulates key molecular mechanisms in the circadian clock. In this paper, we report for the first time that CKI activity undergoes a significant circadian rhythm in the SCN (peaking at circadian time 12, the start of the subjective night), and its pharmacological inhibition alters photic entrainment of the clock, indicating that CKI may be a key element in this pathway.

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Jan 15, 2009·Chronobiology International·Patricia V AgostinoDiego A Golombek

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Citations

May 6, 2009·Molecular and Cellular Biology·Jean-Pierre EtchegarayDavid R Weaver
Aug 21, 2010·Journal of Neurochemistry·Katja SchneiderRainer Spessert
Jul 29, 2010·Physiological Reviews·Diego A Golombek, Ruth E Rosenstein
Mar 9, 2010·Chronobiology International·Jose Antonio SánchezFrancisco Javier Sánchez-Vázquez

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