Circadian biology: rhythms leave their imprint

Current Biology : CB
David W Ray

Abstract

A recent study has revealed that loss of neuronal expression of the paternally imprinted gene Ube3a in Angelman syndrome results in selective neuronal loss of robust circadian oscillations, with a resulting behavioural phenotype, and adipose tissue accumulation.

References

Jan 1, 1989·Archives of Disease in Childhood·S A RobbE M Brett
Feb 3, 2011·Cell Metabolism·Gad Asher, Ueli Schibler
Feb 11, 2015·Current Biology : CB·Shu-qun ShiCarl Hirschie Johnson

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Angelman Syndrome

Angelman syndrome is a neurogenetic imprinting disorder caused by loss of the maternally inherited UBE3A gene and is characterized by generalized epilepsy, limited expressive speech, sleep dysfunction, and movement disorders. Here is the latest research.