PMID: 3761034Sep 1, 1986Paper

Circadian changes in serum and liver metabolites and liver lipogenic enzymes in ad libitum- and meal-fed, lean and obese Zucker rats

The Journal of Nutrition
S Lanza-JacobyM L Kaplan

Abstract

Circadian rhythms were studied in ad libitum- and meal-fed Zucker rats. Lean and obese female rats were fed ad libitum or in a single meal from 1400-1800 for 12 d. Both groups of ad libitum-fed rats exhibited a nocturnal feeding pattern; obese rats ate more than the lean rats during the light and dark parts of the cycle. After 12 d, groups of rats were killed at 4-h intervals over a 24-h period, inclusively, and the presence of circadian rhythms was evaluated for the serum metabolites, liver constituents and the liver lipogenic enzymes. The obese ad libitum-fed rats demonstrated rhythms for serum triglycerides, serum cholesterol, liver protein and glycogen, and the activities of fatty acid synthetase, citrate cleavage enzyme (EC 4.1.3.8), and glucose-6-P dehydrogenase (EC 1.1.1.49). Meal feeding the obese rats modified the rhythms for serum cholesterol, liver glycogen and the activities of glucose-6-P dehydrogenase, and citrate cleavage enzyme and a rhythm was established for serum glucose. The feeding schedule did not cue a rhythm for serum triglycerides and phosphogluconate dehydrogenase (EC 1.1.1.44) or modify the rhythm for liver protein. The lean ad libitum-fed rats displayed rhythms for all the measured parameters except ...Continue Reading

Citations

Nov 12, 2013·Biopharmaceutics & Drug Disposition·Lisl K M ShodaBrett A Howell
Sep 6, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R B BazotteR Curi
Jan 14, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Georgia PapacleovoulouCatherine Williamson
Mar 3, 2007·The Journal of Physiological Sciences : JPS·G PiccioneR Refinetti
Apr 14, 2010·Molecular and Cellular Biology·Fabienne GuillaumondMichèle Teboul
Nov 30, 1992·Biochemical and Biophysical Research Communications·R G NathK Randerath
May 31, 2012·Chemical Research in Toxicology·Gale B Carey, Lisa C Merrill

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