PMID: 9526060Apr 4, 1998Paper

Circadian changes in the expression of vasoactive intestinal peptide 2 receptor mRNA in the rat suprachiasmatic nuclei

Brain Research. Molecular Brain Research
F R CagampangC W Coen

Abstract

The suprachiasmatic nuclei (SCN) in the hypothalamus function as the primary circadian pacemaker. A receptor for vasoactive intestinal peptide (VIP), denoted as VIP2, is abundantly expressed in the SCN. Since the rodent circadian clock demonstrates phase-dependent sensitivity to exogenous VIP, we investigated the possibility that VIP2 receptor mRNA is differentially expressed in the SCN across the 24 h cycle. To establish whether VIP2 receptor mRNA levels change across the 12:12 h light-dark (LD) cycle (lights on designated as Zeitgeber time (ZT)O), rats were killed at ZT 0, 2, 6, 10, 12, 14, 18 and 22. To determine if variation in this mRNA occurs in the absence of LD entrainment cues, lights were not turned on at the time of transition from dark to light (designated as CT O); the animals in this group were killed in constant darkness (DD) at CT 0, 2, 6, 10, 12, 14, 18 and 22. In situ hybridization histochemistry indicated no variations in VIP2 receptor mRNA in the cingulate cortex under either LD or DD conditions. There was, however, significant variation in the expression of VIP2 receptor mRNA within the SCN during the LD cycle, with one peak at ZT 6 and at ZT 22. A comparable biphasic pattern of mRNA expression was observed...Continue Reading

References

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Citations

Nov 12, 2005·Pflügers Archiv : European journal of physiology·Pavel PakhotinHugh Piggins
Jul 17, 2012·Journal of Neural Transmission·G S LallD R Bonsall
Apr 16, 2013·Cell Reports·Pål O Westermark, Hanspeter Herzel
Sep 1, 2000·Brain Research. Brain Research Reviews·K E van EsseveldtG J Boer
Feb 24, 2001·The European Journal of Neuroscience·H E ReedH D Piggins
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·S ShenA J Harmar
Feb 18, 2006·BMC Neuroscience·Stephan MichelChristopher S Colwell
Apr 20, 2014·PLoS Computational Biology·Bharath AnanthasubramaniamHanspeter Herzel
Nov 3, 2015·ELife·William G PembrokePeter L Oliver
Jul 25, 2007·Progress in Neurobiology·Timothy M Brown, Hugh D Piggins
Dec 4, 2003·Journal of Neuroscience Research·Kunihiko KawamotoHitoshi Okamura
Jun 12, 2012·The Journal of Comparative Neurology·Sungwon AnErik D Herzog
Feb 26, 2010·The European Journal of Neuroscience·Joanna M DragichChristopher S Colwell
Feb 18, 2014·Current Biology : CB·Livana Soetedjo, Hua Jin
May 8, 2016·The Journal of Endocrinology·Jennifer A Evans
Dec 22, 2004·The Journal of Physiology·G S BhumbraR E J Dyball
Jun 26, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C S ColwellJ A Waschek
Aug 8, 2018·Journal of Biological Rhythms·David McBride, Linda Petzold
Dec 7, 2018·The European Journal of Neuroscience·Lydia HannouValérie Mongrain
Jul 12, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher S ColwellJames A Waschek
Oct 6, 2001·Chronobiology International·S Michel, C S Colwell
Jun 7, 2013·Journal of Neurophysiology·Takashi KudoChristopher S Colwell
Dec 13, 2005·Brain Research Reviews·L P Morin, C N Allen

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