Circadian clock genes as promising therapeutic targets for autoimmune diseases.

Autoimmunity Reviews
Kun XiangDe-Guang Wang

Abstract

Circadian rhythm is a natural, endogenous process whose physiological functions are controlled by a set of clock genes. Disturbance of the clock genes have detrimental effects on both innate and adaptive immunity, which significantly enhance pro-inflammatory responses and susceptibility to autoimmune diseases via strictly controlling the individual cellular components of the immune system that initiate and perpetuate the inflammation pathways. Autoimmune diseases, especially rheumatoid arthritis (RA), often exhibit substantial circadian oscillations, and circadian rhythm is involved in the onset and progression of autoimmune diseases. Mounting evidence indicate that the synthetic ligands of circadian clock genes have the property of reducing the susceptibility and clinical severity of subjects. This review supplies an overview of the roles of circadian clock genes in the pathology of autoimmune diseases, including BMAL1, CLOCK, PER, CRY, REV-ERBα, and ROR. Furthermore, summarized some circadian clock genes as candidate genes for autoimmune diseases and current advancement on therapy of autoimmune diseases with synthetic ligands of circadian clock genes. The existing body of knowledge demonstrates that circadian clock genes are ...Continue Reading

References

Jan 1, 1992·Journal of Neurochemistry·B KopmelsE E Wollman
Jan 1, 1995·Annual Review of Neuroscience·J S Takahashi
Jul 1, 1993·The International Journal of Neuroscience·R Sandyk, G I Awerbuch
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·J B HogeneschC A Bradfield
Aug 15, 1998·Biochemical and Biophysical Research Communications·S TakahataY Fujii-Kuriyama
Feb 24, 2001·Genome Biology·P E Hardin
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·N Cermakian, P Sassone-Corsi
Sep 12, 2001·Progress in Nucleic Acid Research and Molecular Biology·A M JettenE Ueda
May 11, 2002·Journal of Biological Rhythms·Elizabeth B KlermanRichard E Kronauer
Aug 29, 2002·Nature·Steven M Reppert, David R Weaver
Jan 1, 2003·Cell·Ueli Schibler, Paolo Sassone-Corsi
Jul 17, 2003·The Journal of Biological Chemistry·Katsutaka OishiNorio Ishida
Mar 12, 2004·FEBS Letters·Hideyuki MigitaKohichi Kawai
Aug 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chad A BrautigamJohann Deisenhofer
Nov 4, 2005·Journal of Biological Rhythms·Fabienne GuillaumondNicolas Cermakian
May 6, 2006·Neuron·Jason P DebruyneSteven M Reppert
May 9, 2006·Cell·Masao DoiPaolo Sassone-Corsi
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hongnian GuoEric L Bittman
Aug 9, 2006·Human Molecular Genetics·Ming-Shiu HungUte Christine Rogner
Sep 19, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alvaro Arjona, Dipak K Sarkar
Apr 28, 2007·Human Immunology·Katsuaki AsanoToshio Ogihara
Jul 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gionata CavadiniAdriano Fontana
Jan 15, 2008·Autoimmunity Reviews·Maurizio Cutolo, Rainer H Straub
Jan 26, 2008·Circulation Research·Takeshige KuniedaIssei Komuro
Apr 11, 2008·Immunity·Mandy J McGeachy, Daniel J Cua
Jan 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nancy NaderTomoshige Kino
Feb 12, 2009·Diabetes·Andrew P R SutherlandMatthias von Herrath
Sep 5, 2009·Chronobiology International·Björn Lemmer
Oct 23, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M N Al-HasanL M Baddour
Nov 21, 2009·Integrative Cancer Therapies·Jaclyn GuessWilliam J M Hrushesky
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Nathalie JourniacBéatrice Vernet-der Garabedian
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Maren KellerBert Maier
Jan 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akira HashiramotoShunichi Shiozawa
Feb 13, 2010·Annual Review of Physiology·David K WelshSteve A Kay
Mar 26, 2010·Arthritis Research & Therapy·Kamini ShahInsoo Kang
Jun 19, 2010·Nature Reviews. Immunology·Shimon SakaguchiDavid A Hafler

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

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