Circadian clock neurons constantly monitor environmental temperature to set sleep timing

Nature
Swathi YadlapalliOrie Thomas Shafer

Abstract

Circadian clocks coordinate behaviour, physiology and metabolism with Earth's diurnal cycle. These clocks entrain to both light and temperature cycles, and daily environmental temperature oscillations probably contribute to human sleep patterns. However, the neural mechanisms through which circadian clocks monitor environmental temperature and modulate behaviour remain poorly understood. Here we elucidate how the circadian clock neuron network of Drosophila melanogaster processes changes in environmental temperature. In vivo calcium-imaging techniques demonstrate that the posterior dorsal neurons 1 (DN1ps), which are a discrete subset of sleep-promoting clock neurons, constantly monitor modest changes in environmental temperature. We find that these neurons are acutely inhibited by heating and excited by cooling; this is an unexpected result when considering the strong correlation between temperature and light, and the fact that light excites clock neurons. We demonstrate that the DN1ps rely on peripheral thermoreceptors located in the chordotonal organs and the aristae. We also show that the DN1ps and their thermosensory inputs are required for the normal timing of sleep in the presence of naturalistic temperature cycles. Thes...Continue Reading

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Citations

Jul 31, 2018·The European Journal of Neuroscience·Anna N King, Amita Sehgal
Oct 11, 2019·Journal of Biological Rhythms·Lauren E Foley, Patrick Emery
Nov 27, 2019·Nature Reviews. Molecular Cell Biology·Alina PatkeSofia Axelrod
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Jul 9, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yangbo XiaoSwathi Yadlapalli
Jul 22, 2020·Current Biology : CB·Renny Ng, Chih-Ying Su
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