Circadian clock: Time for novel anticancer strategies?

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Luisa ErcolaniBenedetto Grimaldi

Abstract

Disruption of the circadian clock is associated with a variety of human pathologies, including cancer. Rather than being a mere consequence of a global changes associated with the cancer cell transcriptome, the aberrant clock gene expression observed in many tumors may serve for cancer cell survival. This scenario suggests the provocative hypothesis that pharmacological modulation of clock-related proteins may be suitable as an effective anticancer strategy. In this review, we focus on the functions of the druggable circadian nuclear receptors, REV-ERBα and REV-ERBβ, in cancer cell survival and describe the potential development of small molecule compounds that modulate REV-ERB activity as novel anticancer therapeutics. In addition, we debate the use of circadian rhythm-based synthetic lethal approaches to identify yet unexplored anticancer strategies.

References

Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R J Konopka, S Benzer
Jan 1, 2003·Cell·Ueli Schibler, Paolo Sassone-Corsi
Aug 2, 2003·Nature Reviews. Neuroscience·Michael H HastingsElizabeth S Maywood
Sep 22, 2006·Human Molecular Genetics·Caroline H Ko, Joseph S Takahashi
Nov 27, 2007·Nature Structural & Molecular Biology·Srilatha RaghuramFraydoon Rastinejad
Dec 19, 2007·The Journal of Biological Chemistry·Aline Gréchez-CassiauFranck Delaunay
Jul 26, 2008·Molecular Endocrinology·Michèle TeboulFranck Delaunay
Sep 13, 2008·Journal of Pharmacological Sciences·Adam T StearnsAli Tavakkolizadeh
Sep 27, 2008·The International Journal of Biochemistry & Cell Biology·Benedetto GrimaldiPaolo Sassone-Corsi
Mar 6, 2009·The Lancet Oncology·Monica M ReinholzRobert B Jenkins
Aug 22, 2009·Journal of Applied Physiology·Hélène Duez, Bart Staels
Feb 13, 2010·Annual Review of Physiology·Charna DibnerUrs Albrecht
Mar 20, 2010·Nature Reviews. Cancer·Daniel A TennantEyal Gottlieb
Apr 30, 2010·Endocrinology·Naresh KumarThomas P Burris
Nov 4, 2010·ACS Chemical Biology·Douglas KojetinThomas P Burris
Dec 28, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sashi NadanacivaYvonne Will
Jan 5, 2011·Expert Opinion on Drug Metabolism & Toxicology·Frédéric Gachon, Dmitri Firsov
Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jin Hyup Lee, Aziz Sancar
Feb 22, 2012·Seminars in Cell & Developmental Biology·Dania Daye, Kathryn E Wellen
May 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Quentin McAfeeRavi K Amaravadi
May 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Masafumi ToyoshimaCarla Grandori
Jul 12, 2012·Nature Biotechnology·Heesun CheongCraig B Thompson
Oct 24, 2012·Cancer Management and Research·Jennifer S CarewSteffan T Nawrocki
Jan 5, 2013·Cancer Research·Tomonori KimuraYoshitaka Isaka
Feb 13, 2013·The Biochemical Journal·Claudia C S ChiniEduardo N Chini
Apr 12, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jacob Richards, Michelle L Gumz
May 10, 2013·Journal of Medicinal Chemistry·Ryan P TrumpNicholas C O Tomkinson
Jun 5, 2013·Current Opinion in Neurobiology·Paul E Hardin, Satchidananda Panda
Jun 7, 2013·Expert Opinion on Therapeutic Targets·Knut R SteffensenJan-Åke Gustafsson
Sep 17, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ying ZhengEtty N Benveniste
Nov 28, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Radosław PolańskiChristopher J Morrow
Jan 10, 2014·Nature Reviews. Molecular Cell Biology·Guillermo MariñoGuido Kroemer
Apr 1, 2014·Acta Biochimica Et Biophysica Sinica·Aixia HuangGuoxiang Yao
Apr 22, 2014·FEBS Letters·Mohd Askandar IqbalRameshwar N K Bamezai

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Citations

Apr 4, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dong DongZhijie Li
Apr 14, 2016·Trends in Molecular Medicine·Robert DallmannFrancis Lévi
Feb 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alicia González-GonzálezEmilio J Sánchez-Barceló
Jan 22, 2019·International Journal of Cancer. Journal International Du Cancer·Méyomo G Wendeu-FoyetFlorence Menegaux
Dec 15, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tianpeng ZhangBaojian Wu
Apr 1, 2020·International Journal of Molecular Sciences·Olga BlaževitšBenedetto Grimaldi
Jun 9, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Shenzhen HuangZhijie Li
Aug 14, 2019·British Journal of Pharmacology·Mengjing ZhaoBaojian Wu
Apr 12, 2019·Experimental Dermatology·Yan JiaRuiheng Ding
Jan 23, 2021·Journal of Biological Rhythms·Shaon SenguptaJane A McKeating
Nov 14, 2020·Genome Biology·Luis Enrique Cortés-HernándezCatherine Alix-Panabières

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