Circadian clocks are resounding in peripheral tissues

PLoS Computational Biology
Andrey A PtitsynJeffrey M Gimble

Abstract

Circadian rhythms are prevalent in most organisms. Even the smallest disturbances in the orchestration of circadian gene expression patterns among different tissues can result in functional asynchrony, at the organism level, and may to contribute to a wide range of physiologic disorders. It has been reported that as many as 5%-10% of transcribed genes in peripheral tissues follow a circadian expression pattern. We have conducted a comprehensive study of circadian gene expression on a large dataset representing three different peripheral tissues. The data have been produced in a large-scale microarray experiment covering replicate daily cycles in murine white and brown adipose tissues as well as in liver. We have applied three alternative algorithmic approaches to identify circadian oscillation in time series expression profiles. Analyses of our own data indicate that the expression of at least 7% to 21% of active genes in mouse liver, and in white and brown adipose tissues follow a daily oscillatory pattern. Indeed, analysis of data from other laboratories suggests that the percentage of genes with an oscillatory pattern may approach 50% in the liver. For the rest of the genes, oscillation appears to be obscured by stochastic n...Continue Reading

References

Feb 1, 1981·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M Goubern, R Portet
Apr 4, 2002·Annals of Clinical Biochemistry·M P ArasaradnamR Gama
Apr 23, 2002·Nature·Kai-Florian StorchCharles J Weitz
May 23, 2002·Cell·Satchidananda PandaJohn B Hogenesch
Nov 28, 2002·Nature Genetics·Gary A Churchill
Jun 6, 2003·Current Opinion in Genetics & Development·Urs Albrecht, Gregor Eichele
Jul 17, 2003·The Journal of Biological Chemistry·Katsutaka OishiNorio Ishida
Dec 4, 2003·The International Journal of Biochemistry & Cell Biology·Toralph RugeGunilla Olivecrona
Dec 25, 2003·Bioinformatics·Sofia WichertKorbinian Strimmer
Mar 29, 2006·Diabetes·Sanjin ZvonicJeffrey M Gimble

❮ Previous
Next ❯

Citations

Jun 13, 2014·PloS One·Carlo C LazadoJorge M O Fernandes
Apr 5, 2012·ISRN Endocrinology·Wai W Cheung, Peizhong Mao
Mar 25, 2014·Journal of Neuroinflammation·Ian A Clark, Bryce Vissel
Jan 29, 2014·Physiology & Behavior·Marta Garaulet, Purificación Gómez-Abellán
Sep 12, 2014·Nature Communications·Jeffrey A HaspelAugustine M K Choi
Nov 23, 2006·BMC Bioinformatics·Andrey A PtitsynJeffrey M Gimble
Jun 19, 2007·PLoS Computational Biology·Andrey A PtitsynJeffrey M Gimble
Apr 26, 2008·Annual Review of Nutrition·Daniel PompDaria Estrada-Smith
Jan 10, 2009·Journal of Dental Research·Y GafniD Gazit
Feb 11, 2009·BMC Medical Genomics·Andrey LobodaPek Yee Lum
May 28, 2009·Journal of Applied Physiology·Jeffrey M Gimble, Z Elizabeth Floyd
Sep 24, 2009·Bioinformatics·Darya ChudovaPadhraic Smyth
Oct 13, 2010·Molecular and Cellular Biology·Fumiyuki HatanakaToru Takumi
Dec 8, 2010·Cardiovascular Diabetology·Sol M Rodríguez-ColónDuanping Liao
Mar 19, 2011·BMC Genomics·Andrey A PtitsynWilliam C Black
Jun 23, 2012·Genome Biology·Nicholas J McGlincyJernej Ule
Jan 30, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M GarauletF A J L Scheer
Jul 4, 2012·Nucleic Acids Research·Yukimasa TakedaAnton M Jetten
Jul 19, 2011·Journal of Bone and Mineral Metabolism·Tadahiro IimuraAkira Yamaguchi
Jun 10, 2014·FEBS Letters·I Robinson, A B Reddy
Aug 21, 2007·FEBS Letters·Aaron D LaposkyFred W Turek
Jun 15, 2011·Molecular and Cellular Endocrinology·Jonathan D Johnston
Feb 2, 2010·Plant Physiology and Biochemistry : PPB·Christa GaskillSigrid Jacobshagen
Jul 13, 2007·Biochemical and Biophysical Research Communications·Brian C GohJeffrey M Gimble
Dec 5, 2006·Trends in Endocrinology and Metabolism : TEM·Akira Kohsaka, Joseph Bass
Apr 23, 2009·Journal of Cellular Biochemistry·Jeffrey M GimbleBruce A Bunnell
Oct 29, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K BegricheA A Butler
Oct 29, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J M GimbleZ E Floyd
Oct 29, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J D JohnstonD T Otway
Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sanjin ZvonicJeffrey M Gimble
Mar 21, 2007·Obesity·Adrian M StützGeorge Argyropoulos
Jan 31, 2012·Journal of Thrombosis and Haemostasis : JTH·C J TraceyP S Hartley
Sep 4, 2015·Diabetes, Obesity & Metabolism·E M Scott
Jan 24, 2014·Biochemical Society Transactions·Lisa Wu, Akhilesh B Reddy
Sep 27, 2013·Molecular Genetics and Metabolism·Derek O'NeilKjersti M Aagaard

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
chips

Software Mentioned

Hogenesch
R
GeneChip Operating Software
Spotfire Decisionsite
Affymetrix

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Sanjin ZvonicJeffrey M Gimble
© 2021 Meta ULC. All rights reserved