Circadian dependency of nocturnal immediate-early protein induction in rat retina

Biochemical and Biophysical Research Communications
Ann Humphries, David A Carter

Abstract

Daily rhythms in the mammalian retina are regulated by an endogenous circadian clock. Previously it was found that neuronal elements of the rat retina respond to light:dark (L:D) transitions with cell-specific changes in expression of the c-fos gene. Using a pan-Fos antibody to probe Western blots of rat retina, we have now shown that darkness is associated with a 60-fold increase in c-Fos protein, whereas levels of FosB and Fos-related antigens are invariant. The induction of c-Fos exhibits circadian dependency; accumulation of c-Fos protein was significantly enhanced, by a factor of 2.5-fold, when darkness onset was coincident with the established L:D transition. c-Fos exhibited only a low amplitude circadian rhythm in the absence of L:D cycles. Similar results were obtained for another immediate early gene (IEG) protein, Egr-1. These findings show that IEG induction in the rodent retina exhibits circadian clock dependency.

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Citations

Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jin Hyup Lee, Aziz Sancar
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·K-F StorchC J Weitz
Apr 23, 2005·Progress in Retinal and Eye Research·P Michael IuvoneShyam S Chaurasia
Jan 17, 2008·Cellular & Molecular Biology Letters·Jia HuangPing Xu
Jun 7, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Gianluca TosiniP Michael Iuvone
Apr 11, 2021·Experimental Eye Research·Zhijie WangShibo Tang

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