PMID: 6400662Jan 1, 1984Paper

Circadian dependent effect of epidermal growth factor, insulin and glucagon on hepatic pyruvate kinase and malic enzyme of mice

Chronobiology International
R J FeuersD A Casciano

Abstract

The influence of epidermal growth factor (EGF), 0.75 micrograms g1; insulin, 1.5 micrograms g-1; glucagon, 1.25 micrograms g-1 and their combinations on the activities of hepatic pyruvate kinase (PK) and malic enzymes (ME) was monitored. Male CD2F1 mice were treated toward the end of the light or dark periods, 9 or 23 hours after lights on (9 or 23 HALO), and subgroups of six mice were killed at 4, 8 or 12 hr post-treatment. PK and ME activities from control mice were well characterized by cosine curves. The PK activity was maximal when ME activity was minimal at the transition from light to dark (9 HALO plus 4 hr) and PK was at a minimum when ME was highest (23 HALO plus 4 hr). Both enzymes were influenced by at least one peptide hormone, and the effects were strongly circadian-stage dependent. The only effect attributed to EGF was an increase of PK activity (23%) 12 hr after injection at 23 HALO. PK activity was increased by insulin (23%) at 23 HALO (4 hr after injection), but not at 9 HALO, and decreased (17%) by glucagon 12 hr after injection at 9 HALO. Several reductions in PK activity in response to various combinations of peptides were observed, and appeared to be caused by glucagon but influenced by insulin.(ABSTRACT TR...Continue Reading

References

Dec 30, 1976·The New England Journal of Medicine·M FarivarN L Bucher
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R A RichmanD L Friedman
Sep 1, 1974·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H LaubeE F Pfeiffer
Sep 1, 1980·Archives of Biochemistry and Biophysics·D M Moriarity, C R Savage
Jan 1, 1981·Endocrine Reviews·S Jacobs, P Cuatrecasas
Nov 1, 1981·The American Journal of Anatomy·C NorthD A Casciano

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Citations

Nov 24, 2011·Apoptosis : an International Journal on Programmed Cell Death·Sven GottschalkMarc Bilodeau
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·Y G Kaminsky, E A Kosenko
Jan 1, 1994·Journal of Paleolimnology·P T DoranW B Lyons

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