Circadian disruption and biomarkers of tumor progression in breast cancer patients awaiting surgery

Brain, Behavior, and Immunity
E CashFirdaus S Dhabhar

Abstract

Psychological distress, which can begin with cancer diagnosis and continue with treatment, is linked with circadian and endocrine disruption. In turn, circadian/endocrine factors are potent modulators of cancer progression. We hypothesized that circadian rest-activity rhythm disruption, distress, and diurnal cortisol rhythms would be associated with biomarkers of tumor progression in the peripheral blood of women awaiting breast cancer surgery. Breast cancer patients (n=43) provided actigraphic data on rest-activity rhythm, cancer-specific distress (IES, POMS), saliva samples for assessment of diurnal cortisol rhythm, cortisol awakening response (CAR), and diurnal mean. Ten potential markers of tumor progression were quantified in serum samples and grouped by exploratory factor analysis. Analyses yielded three factors, which appear to include biomarkers reflecting different aspects of tumor progression. Elevated factor scores indicate both high levels and strong clustering among serum signals. Factor 1 included VEGF, MMP-9, and TGF-β; suggesting tumor invasion/immunosuppression. Factor 2 included IL-1β, TNF-α, IL-6R, MCP-1; suggesting inflammation/chemotaxis. Factor 3 included IL-6, IL-12, IFN-γ; suggesting inflammation/TH1-typ...Continue Reading

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Citations

Oct 20, 2015·Journal of Cellular Biochemistry·Annamaria Chiara SantiniMarina Di Domenico
Jan 16, 2016·Journal of Psychosocial Oncology·Bryan J EvansHeather S L Jim
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May 25, 2021·British Journal of Pharmacology·Myrthe MampayGraham K Sheridan

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