Circadian disruption-induced metabolic syndrome in mice is ameliorated by oat β-glucan mediated by gut microbiota.

Carbohydrate Polymers
Wai-Yin ChengPeter Chi-Keung Cheung

Abstract

Circadian disruption-induced metabolic syndrome (CDIMS) involves body weight gain, changes in blood profile and gut microbiota. In this study, CDIMS was induced by shifted light dark cycle (SLDC) in C57BL/6J mice. Dietary intervention by oral administration of oat β-glucan (a polymeric prebiotic) alleviated CDIMS when compared to chicory inulin/fructan (an oligomeric prebiotic) and melatonin (a chronobiotic). Oat β-glucan reversed the increase in body weight, liver weight-to-body weight ratio and plasma leptin concentration as well as restored glucose tolerance. In altering gut microbiota, oat β-glucan increased the species richness, reversed the populations of 7 bacterial genera and increased butyrate producers including Ruminococcaceae and Lachnospiraceae which enhance gut barrier protection and regulate glucose homeostasis. Correlation analysis demonstrated the linking of the alleviation of CDIMS by prebiotics and melatonin with different microbial metabolic pathways involved in energy metabolism, biosynthesis of metabolites, metabolism of cofactors and vitamins and endocrine synthesis.

References

Jan 16, 1997·The New England Journal of Medicine·A Brzezinski
May 10, 2000·The Journal of Nutrition·E MenneM Roberfroid
Mar 15, 2003·Occupational Medicine·Anders Knutsson
Feb 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Seung-Hee YooJoseph S Takahashi
Feb 1, 1996·Applied Ergonomics·G Costa
Apr 23, 2005·Science·Fred W TurekJoseph Bass
Jul 8, 2005·Scandinavian Journal of Work, Environment & Health·Yuko MorikawaKoji Nogawa
Oct 6, 2005·Applied and Environmental Microbiology·Maddalena RossiDiego Matteuzzi
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Apr 24, 2008·FEMS Microbiology Ecology·Simon A HughesRobert A Rastall
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Katja A LamiaCharles J Weitz
Dec 2, 2008·Mechanisms of Ageing and Development·Oren FroyRuth Miskin
Jan 31, 2009·Endocrinology·Shutong YangJay H Chung
Jun 12, 2009·Journal of Hematology & Oncology·Godfrey Chi-Fung ChanDaniel Man-Yuen Sze
Aug 3, 2010·Cell Metabolism·Xiaoyue PanM Mahmood Hussain
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ilia N KaratsoreosBruce S McEwen
Dec 16, 2011·Nature·Katja A LamiaRonald M Evans
Feb 26, 2013·Current Biology : CB·Shu-qun ShiCarl Hirschie Johnson
Aug 21, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L K BraheL H Larsen
May 23, 2014·PloS One·Robin M VoigtAli Keshavarzian
Aug 8, 2014·Current Nutrition Reports·Hideaki OikeMasuko Kobori
Dec 4, 2014·Cell Metabolism·Amir ZarrinparSatchidananda Panda
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Aug 5, 2015·Proceedings of the National Academy of Sciences of the United States of America·Xue LiangGarret A FitzGerald
Sep 18, 2015·Science Translational Medicine·Tina M BurkeKenneth P Wright
May 15, 2016·Carbohydrate Polymers·Muhammad ShoaibSobia Niazi
Jun 19, 2016·Lipids in Health and Disease·Othman A BaothmanMohamed Abu-Farha
Feb 16, 2017·Journal of Pineal Research·Pengfei XuYonggong Zhai
Aug 31, 2017·The Journal of Endocrinology·Adrián Báez-RuizRuud M Buijs

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