Circadian effect on carbamazepine kinetics in rat

European Journal of Drug Metabolism and Pharmacokinetics
B BruguerolleP Bouyard

Abstract

The purpose of the present study was to investigate whether the time of day (24 h) at which carbamazepine is administered influences its pharmacokinetics in the rat. The pharmacokinetics of a single, 100 mg . kg-1 bodyweight per os, dose of carbamazepine were studied at four different fixed time points of a 24-hour period (i.e. 10.00, 16.00, 22.00 or 04.00 h) in Wistar AF-SPF adult male rats maintained under controlled environmental conditions (LD: 18.00 - 06.00h) during October 1978. The total plasma levels and the unbound fraction were measured according to an immunoenzymatic method (EMIT). The effects of fasting were also investigated. The data shows circadian variations of pharmacokinetic parameters: the maximum peak concentration and the maximum time to reach this peak was observed when the drug was given respectively at 16.00h and at 10.00h. The elimination half-life varied from 15.15 hours at 16.00h to 10.48 hours at 22.00h. The observed variations may be related to: daily fluctuations of absorption or binding of the drug; diurnal variations of the hepatic drug metabolizing enzymes responsible for the inactivation; and/or diurnal variations in excretion rate of the drug.

References

Apr 1, 1979·Epilepsia·J S LockardI H Patel
Aug 1, 1977·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J M Tredger, R S Chhabra
Nov 1, 1977·Acta Pharmacologica Et Toxicologica·S Pynnönen
Dec 28, 1977·European Journal of Clinical Pharmacology·L M CotterJ H Tyrer
Aug 1, 1975·The Journal of Infectious Diseases·M BarzaL Weinstein
Dec 1, 1977·Clinical Pharmacology and Therapeutics·E S VesellG T Passananti
Oct 1, 1975·Clinical Pharmacology and Therapeutics·C A Shively, E S Vesell
Nov 1, 1973·Clinical Pharmacology and Therapeutics·M C Ede
Nov 1, 1968·The American Journal of Physiology·L E SchevingT H Tsai
Jan 1, 1971·Annual Review of Pharmacology·A Reinberg, F Halberg
Nov 1, 1971·Biochemical Pharmacology·A JoriV Santini
Aug 1, 1971·Biochemical Pharmacology·P L MorselliS Garattini

❮ Previous
Next ❯

Citations

May 9, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nina HimmerkusMarkus Bleich
Aug 21, 2007·Journal of Pharmaceutical Sciences·Bernard BruguerolleNicolas Simon
Oct 20, 2006·Chronobiology International·Radha YegnanarayanShashi Sangle
Jan 1, 1984·Chronobiology International·B Bruguerolle
Jan 1, 1991·Annals of the New York Academy of Sciences·C J Carr
Mar 1, 2013·Epilepsy Currents·Jennifer L DewolfeGregory L Holmes
May 4, 2004·Mutation Research·Varsha G DesaiJames C Fuscoe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.