Circadian effects of dopaminergic treatment in restless legs syndrome

Sleep Medicine
D Garcia-BorregueroJuan José Granizo

Abstract

Although an essential diagnostic feature of restless legs syndrome (RLS) is the presence of circadian symptom variations, with an increase in the evening or at night, the mechanisms underlying this time-bound variation remain unknown. Since dopaminergic mechanisms seem to play a central role in the pathophysiology of RLS, it is likely that circadian variations in the dopaminergic system or factors affecting it cause the nightly increase. The reverse is also possible; dopaminergic medication might affect melatonin function, a key element of the circadian system. The present study investigated the effects of dopaminergic medication on melatonin secretion in RLS. Eight previously untreated patients diagnosed with idiopathic RLS underwent a three-week, open-labeled treatment with 400 mg L-DOPA (+100 mg CarbiDOPA). Dim Light Melatonin Onset (DLMO), a marker of circadian phase, was determined before and after treatment. Compared to baseline, earlier DLMO was found in L-DOPA treated patients (21:00+/-1:20 vs. 18:50+/-0:55; P < 0.05). Anticipation of DLMO was more marked in the subgroup of patients showing augmentation. A positive correlation was observed between change of DLMO, sleep latency and time of onset of symptoms following tre...Continue Reading

References

Jun 1, 1977·Journal of Neurochemistry·M J PerlowT N Chase
Jan 1, 1991·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·E FertlF Waldhauser
Feb 26, 1982·Biochemical and Biophysical Research Communications·N Zisapel, M Laudon
Jan 1, 1993·Brain Research Bulletin·N A Alexiuk, J P Vriend
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·E FertlF Waldhauser
Sep 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·A S Walters
Feb 1, 1997·Journal of Biological Rhythms·S W LockleyJ Arendt
Apr 16, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·J MontplaisirG Lavigne
Aug 19, 1999·Journal of Biological Rhythms·A J LewyR L Sack
Sep 4, 1999·Journal of Sleep Research·M C GordijnR H van den Hoofdakker
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·R Andretic, J Hirsh
Jul 25, 2000·Archives of Internal Medicine·B PhillipsC Purvis
Feb 24, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·C J EarleyR P Allen
Oct 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·K Kräuchi, A Wirz-Justice
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D J KennawayR W Moyer
Nov 1, 2003·Sleep Medicine·R P AllenC J Earley
Nov 1, 2003·Sleep Medicine·D Garcia-BorregueroY de la Llave
Mar 25, 2009·Neoplasma·B BojkovaI Ahlers

❮ Previous
Next ❯

Citations

Sep 23, 2014·Current Treatment Options in Neurology·William G Ondo
Jul 2, 2008·Current Neurology and Neuroscience Reports·Lynn Marie TrottiDavid B Rye
May 20, 2008·CNS Drugs·Pankaj Satija, William G Ondo
Mar 12, 2010·Sleep Medicine Reviews·Diego García-Borreguero, Anne-Marie Williams
Jun 21, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Diego García-BorregueroJuliane Winkelmann
Sep 22, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L VignatelliUNKNOWN EFNS Task Force
Jan 22, 2011·European Journal of Clinical Investigation·Mehmet Ali CikrikciogluTufan Tukek
Mar 28, 2006·Sleep Medicine·Birgit Högl
Aug 28, 2012·Parkinsonism & Related Disorders·S Rios RomenetsR B Postuma
Dec 24, 2013·Journal of the Neurological Sciences·Naomichi FurudateYuichi Inoue
Oct 18, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Claudia TrenkwalderCristina Sampaio
Jun 25, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ambra Stefani, Birgit Högl
Nov 5, 2021·Psychiatry Investigation·Jae Eun SeoHeon-Jeong Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.