Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo

Oncotarget
Niu ZhanfengXia Hechun

Abstract

Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report here that although both genes were expressed with a circadian rhythm in glioma and normal brain tissue in rats, their expression profiles differed in the two types of tissue. In addition, high expression of Per1 and Per2 in glioma tissue was associated with increased sensitivity to x-irradiation. No such sensitizing effect was observed in normal tissue. Our results suggest that Per1 and Per2 expression may increase the efficacy of radiotherapy against glioma by promoting apoptosis.

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Citations

Jun 18, 2017·Frontiers in Physiology·Alexandre ValléeJean-Noël Vallée
Nov 16, 2019·Journal of Neuro-oncology·Dorela D Shuboni-MulliganTerri S Armstrong
Mar 21, 2020·Frontiers in Oncology·Kholoud Arafa, Marwan Emara
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May 29, 2021·Frontiers in Oncology·Luis Bermúdez-GuzmánEduardo Lovo
Jul 18, 2021·Trends in Cell Biology·Wenjing XuanPeiwen Chen

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Methods Mentioned

BETA
irradiating
light microscopy
PCR

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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