Circadian Modulation of Alcohol-Induced Sedation and Recovery in Male and Female Drosophila

Journal of Biological Rhythms
Aliza K De Nobrega, Lisa C Lyons

Abstract

Delineating the factors that affect behavioral and neurological responses to alcohol is critical to facilitate measures for preventing or treating alcohol abuse. The high degree of conserved molecular and physiological processes makes Drosophila melanogaster a valuable model for investigating circadian interactions with alcohol-induced behaviors and examining sex-specific differences in alcohol sensitivity. We found that wild-type Drosophila exhibited rhythms in alcohol-induced sedation under light-dark and constant dark conditions with considerably greater alcohol exposure necessary to induce sedation during the late (subjective) day and peak sensitivity to alcohol occurring during the late (subjective) night. The circadian clock also modulated the recovery from alcohol-induced sedation with flies regaining motor control significantly faster during the late (subjective) day. As predicted, the circadian rhythms in sedation and recovery were absent in flies with a mutation in the circadian gene period or arrhythmic flies housed in constant light conditions. Flies lacking a functional circadian clock were more sensitive to the effects of alcohol with significantly longer recovery times. Similar to other animals and humans, Drosop...Continue Reading

References

Feb 1, 1988·Alcoholism, Clinical and Experimental Research·C L Arfken
Sep 1, 1972·The Proceedings of the Nutrition Society·J C McKenzie
Mar 1, 1984·Alcoholism, Clinical and Experimental Research·J BrickM N Adams
Nov 22, 2000·Neuron·H ScholzU Heberlein
Feb 7, 2001·The American Journal of Psychiatry·A PfefferbaumE Sullivan
Feb 7, 2001·The American Journal of Psychiatry·D HommerR Rawlings
Apr 12, 2001·Australian and New Zealand Journal of Public Health·E C Wigglesworth
Oct 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yesser Hadj Belgacem, Jean-René Martin
Dec 18, 2002·Journal of Neurobiology·Fred W Wolf, Ulrike Heberlein
Jun 6, 2003·International Review of Neurobiology·Douglas J Guarnieri, Ulrike Heberlein
Nov 1, 1959·Journal of Applied Physiology·E HAUS, F HALBERG
Dec 19, 2003·Chronobiology International·Thierry DanelYvan Touitou
May 14, 2004·Genes, Brain, and Behavior·W ChoF W Wolf
Jul 31, 2004·Sleep·Reto HuberChiara Cirelli
Jan 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Tieqiao WenPing Shen
Apr 9, 2005·Methods in Enzymology·Rozi Andretic, Paul J Shaw
Nov 5, 2005·Alcoholism, Clinical and Experimental Research·R B CowmeadowN S Atkinson
Dec 13, 2005·Genome Research·Michael Ashburner, Casey M Bergman
Jul 21, 2006·The Journal of Comparative Neurology·Orie Thomas ShaferPaul H Taghert
Aug 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Gyunghee LeeJae H Park
Sep 22, 2006·Human Molecular Genetics·Caroline H Ko, Joseph S Takahashi
Dec 1, 2006·International Journal of Food Sciences and Nutrition·Sarita SrivastavaRajesh Prakash Srivastava
Feb 6, 2007·Current Biology : CB·Shinsuke FujiiHubert Amrein
Apr 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nancy L UrizarRonald L Davis
Jan 3, 2008·PloS One·Hyun-Gwan LeeKyung-An Han
Dec 23, 2008·Journal of Neurogenetics·Henrike Scholz
Jan 2, 2009·Learning & Memory·Lisa C Lyons, Gregg Roman
Jun 16, 2009·Addiction Biology·Stéphanie Perreau-LenzAinhoa Bilbao
Oct 2, 2009·Proceedings. Biological Sciences·R Elwyn IsaacAlan D Shirras
Dec 17, 2009·Current Biology : CB·Anita V Devineni, Ulrike Heberlein
Feb 13, 2010·Annual Review of Physiology·Ravi Allada, Brian Y Chung
Apr 27, 2010·Trends in Cognitive Sciences·Charalambos P Kyriacou, Michael H Hastings

❮ Previous
Next ❯

Citations

Oct 1, 2018·The European Journal of Neuroscience·Aliza K De Nobrega, Lisa C Lyons
Sep 5, 2018·Biological Trace Element Research·Paula Tais Halmenschelager, João Batista Teixeira da Rocha
Mar 30, 2018·Frontiers in Physiology·Rajeswari KoyyadaStefano O Casalotti
May 4, 2018·Frontiers in Physiology·Eve G Lowenstein, Norma A Velazquez-Ulloa

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation
Assay

Software Mentioned

GraphPad Prism
GraphPad

Related Concepts

Related Feeds

Alcohol Use Disorder

Alcohol use disorder involves a pattern of alcohol consumption that includes compulsive use and a loss of control over intake of alcohol. The impact on physical health, socioeconomic factors, and psychiatric health is profound. Find the latest research on alcohol use disorder here.