Circadian modulation of human erythrocyte plasma membrane redox system by melatonin

Neuroscience Letters
Shilpa Chakravarty, Syed Ibrahim Rizvi

Abstract

The pineal hormone melatonin works for the stabilization of biological rhythms, however, it also modulates several other functions such as cardioprotection, thermoregulation and immunomodulation. Melatonin also shows antioxidant activity. The erythrocyte plasma membrane redox system (PMRS) alongwith ascorbate free radical (AFR) reductase is involved in providing protection against oxidative stress. The present work is an ex vivo study addressing RBC PMRS and AFR reductase activities at two different times of the day. The in vitro modulatory effect of melatonin on PMRS and AFR reductase activities is also reported. The study was carried out on 61 healthy donors of both sexes (aged 20-30). Blood samples were collected at two different timings viz., 10:00 a.m. and 10:00 p.m. PMRS and AFR reductase were determined by methods already reported. The concentration-dependent effect of the melatonin was evaluated by incubating the RBCs with the hormone at different doses. We present results to show that erythrocyte PMRS and AFR reductase activity are modulated by melatonin, a higher activity (p<0.05) of PMRS and AFR reductase is observed during night when the level of melatonin is high. The effect of in vitro treatment of erythrocytes wi...Continue Reading

References

Jan 7, 2000·Biochemical and Biophysical Research Communications·J M MayC E Cobb
Jun 29, 2000·The Journal of Biological Chemistry·M M VanDuijnJ Van Der Zee
Dec 1, 1963·Analytical Biochemistry·M AVRON, N SHAVIT
May 12, 2004·Biochemical Pharmacology·Matthew J GerdinMargarita L Dubocovich
Mar 1, 1995·Archives of Gerontology and Geriatrics·C PieriR Recchioni
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matthew J GerdinMargarita L Dubocovich
Oct 12, 2005·Endocrine·Margarita L Dubocovich, Magdalena Markowska
May 16, 2006·Ageing Research Reviews·Dong-Hoon HyunRafael de Cabo
Jul 5, 2006·The FEBS Journal·S R Pandi-PerumalR Hardeland
Nov 16, 2006·Rejuvenation Research·Syed Ibrahim RizviPawan Kumar Maurya
Dec 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Dong-Hoon HyunRafael de Cabo
Dec 17, 2008·Rejuvenation Research·Syed Ibrahim RizviPawan Kumar Maurya
Jun 9, 2009·Free Radical Biology & Medicine·Darius J R Lane, Alfons Lawen
Jul 29, 2009·Critical Reviews in Biochemistry and Molecular Biology·Russel J ReiterDan-Xian Tan
Dec 21, 2010·Experimental Neurology·P A Adlard, A I Bush
Jan 21, 2011·Medical Hypotheses·Syed Ibrahim RizviPrabhakar Singh

❮ Previous
Next ❯

Citations

Dec 4, 2012·Antioxidants & Redox Signaling·Melissa WilkingNihal Ahmad
Oct 17, 2013·International Journal of Molecular Sciences·Sylvie TordjmanJulie Vernay-Leconte
Dec 30, 2014·Journal of Pineal Research·Danilo Grünig Humberto da SilvaClaudia Regina Bonini-Domingos
Jul 12, 2017·Expert Opinion on Drug Discovery·Komal Saraswat, Syed Ibrahim Rizvi
Aug 1, 2020·Chronobiology International·Avnish Kumar VermaSyed Ibrahim Rizvi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.