PMID: 8615420May 1, 1996Paper

Circadian pattern of acute, neuroleptic-induced dystonic reactions

The American Journal of Psychiatry
M F Mazurek, P I Rosebush

Abstract

This study examined the timing of acute dystonic reactions in 200 patients taking neuroleptic medication for the first time. Two hundred patients received a twice-daily regimen of low-dose neuroleptic. Over 80% of the episodes of acute dystonia occurred between 12:00 noon and 11:00 p.m. The observed circadian variation was not accounted for by sleep, fatigue, or time elapsed from the last dose of medication. The finding of a diurnal pattern in one of the recognized side effects of neuroleptic medication suggests that the therapeutic efficacy of neuroleptics might similarly vary over the course of the day.

Citations

Oct 7, 2005·Journal of Neurology·D Dressler, R Benecke
Mar 1, 1997·Biological Psychiatry·A E StroeP J Knott
Oct 2, 2003·The Annals of Pharmacotherapy·Stanford S JheeSteve J Sims
Mar 1, 1997·Annals of Neurology·W J Schwartz
Oct 2, 2003·Journal of Clinical Psychopharmacology·Hiroyuki UchidaHaruo Kashima
Jun 4, 2008·Clinical Neuropharmacology·Samir Kumar PraharajPrasenjit Ray
May 11, 2006·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Kazuhiko Abe
Feb 22, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Elizabeth J Slow, Anthony E Lang

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