PMID: 1204869Oct 1, 1975Paper

Circadian periodicity of blood coagulation system indices and the hormonal activity of the adrenals in healthy persons (under conditions of rest and of stressed work)

Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova
G P Deriagina, V Iu Krivskaia

Abstract

13 patients with the heart ischemic disease (HID) were examined in conditions of a relative rest (hospital) and 20 patients - during an intensive day work. Within the 24-hr rhythm of gemocoagulation parameters, 3 phases were distinguished (conventionally): I a tendency to hypercoagulation at 0-3-6 a.m.; II the most safe period at 9 a.m.; III an increased ability of coagulation at 12-3-6-9 p.m. During the intensive day work, hypercoagulative shifts become more obvious and the anticoagulating system becomes activated at the I and the III phases. Within the 24: hr rhythm of the plasma fibrinolytic activity, 2 phases were distinguished (conventionally): I low activity at 0-3-6-9-12 a.m.; II sufficient activity at 3-6-9 p.m. During the intensive day work fibrinolytic activity increases, and the character of 24-hr rhythm preserves. Within the 24-hr rhythm of the adrenal hormonal activity, 3 phases were distinguished (conventionally): I a reduced activity at 0-3-6 a.m.; II high activity at 9 a.m.; III high enough activity at 12-3-6-9 p.m. In conditions of intensive day work the 24-hr rhythm of the adrenal hormonal activity does not change.

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