Circadian regulation of a-type potassium currents in the suprachiasmatic nucleus.

Journal of Neurophysiology
Jason N ItriChristopher S Colwell

Abstract

In mammals, the precise circadian timing of many biological processes depends on the generation of oscillations in neural activity of pacemaker cells in the suprachiasmatic nucleus (SCN) of the hypothalamus. Understanding the ionic mechanisms underlying these rhythms is an important goal of research in chronobiology. Previous work has shown that SCN neurons express A-type potassium currents (IAs), but little is known about the properties of this current in the SCN. We sought to characterize some of these properties, including the identities of IA channel subunits found in the SCN and the circadian regulation of IA itself. In this study, we were able to detect significant hybridization for Shal-related family members 1 and 2 (Kv4.1 and 4.2) within the SCN. In addition, we used Western blot to show that the Kv4.1 and 4.2 proteins are expressed in SCN tissue. We further show that the magnitude of the IA current exhibits a diurnal rhythm that peaks during the day in the dorsal region of the mouse SCN. This rhythm seems to be driven by a subset of SCN neurons with a larger peak current and a longer decay constant. Importantly, this rhythm in neurons in the dorsal SCN continues in constant darkness, providing an important demonstrati...Continue Reading

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Citations

Apr 2, 2011·Journal of Biological Rhythms·Karen L GambleDouglas G McMahon
Aug 31, 2013·PLoS Computational Biology·Casey O DiekmanDaniel B Forger
Jul 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel Granados-FuentesErik D Herzog
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Nov 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jongbin LeeRavi Allada

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