Circadian Rhythm in Cytokines Administration

Mini Reviews in Medicinal Chemistry
Valery A Trufakin, Anna V Shurlygina

Abstract

In recent times, a number of diseases involving immune system dysfunction have appeared. This increases the importance of research aimed at finding and developing optimized methods for immune system correction. Numerous studies have found a positive effect in using cytokines to treat a variety of diseases, yet the clinical use of cytokines is limited by their toxicity. Research in the field of chronotherapy, aimed at designing schedules of medicine intake using circadian biorhythms of endogenous production of factors, and receptors' expression to the factors on the target cells, as well as chronopharmacodynamics and chronopharmacokinetics of medicines may contribute to the solution of this problem. Advantages of chronotherapy include a greater effectiveness of treatment, reduced dose of required drugs, and minimized adverse effects. This review presents data on the presence of circadian rhythms of spontaneous and induced cytokine production, as well as the expression of cytokine receptors in the healthy body and in a number of diseases. The article reviews various effects of cytokines, used at different times of the day in humans and experimental animals, as well as possible mechanisms underlying the chronodependent effects of ...Continue Reading

Citations

Nov 20, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Mette Marie RelsterCourt Pedersen
Mar 7, 2020·Journal of Neurology·Francesco PattiUNKNOWN RELIEF Study Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

Journal of Neurology, Neurosurgery, and Psychiatry
Lea Glass-MarmorAriel Miller
Revista clínica española
J Merino Sánchez, V F Gil Guillén
© 2021 Meta ULC. All rights reserved