Circadian rhythm influences induction of trained immunity by BCG vaccination.

The Journal of Clinical Investigation
L Charlotte J de BreeMihai G Netea

Abstract

BACKGROUNDThe antituberculosis vaccine bacillus Calmette-Guérin (BCG) reduces overall infant mortality. Induction of innate immune memory, also termed trained immunity, contributes toward protection against heterologous infections. Since immune cells display oscillations in numbers and function throughout the day, we investigated the effect of BCG administration time on the induction of trained immunity.METHODSEighteen volunteers were vaccinated with BCG at 6 pm and compared with 36 age- and sex-matched volunteers vaccinated between 8 am and 9 am. Peripheral blood mononuclear cells were stimulated with Staphylococcus aureus and Mycobacterium tuberculosis before, as well as 2 weeks and 3 months after, BCG vaccination. Cytokine production was measured to assess the induction of trained immunity and adaptive responses, respectively. Additionally, the influence of vaccination time on induction of trained immunity was studied in an independent cohort of 302 individuals vaccinated between 8 am and 12 pm with BCG.RESULTSCompared with evening vaccination, morning vaccination elicited both a stronger trained immunity and adaptive immune phenotype. In a large cohort of 302 volunteers, early morning vaccination resulted in a superior cyto...Continue Reading

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Citations

Aug 20, 2020·The Journal of Clinical Investigation·S Prentice, H M Dockrell
Jan 23, 2021·Journal of Biological Rhythms·Shaon SenguptaJane A McKeating
Nov 7, 2020·International Reviews of Immunology·Vijay Kumar
Mar 23, 2021·International Immunology·Akiko NakaiKazuhiro Suzuki
Sep 3, 2021·Cell Research·Coline BarnoudChristoph Scheiermann
Sep 23, 2021·Journal of Biological Rhythms·Yool LeeAmita Sehgal
Sep 19, 2021·FEBS Letters·Junyan DuanBogi Andersen
Oct 27, 2021·Journal of Biological Rhythms·Candace D McNaughtonThomas A Lasko

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Methods Mentioned

BETA
blood collection
blood drawing
ELISA
flow cytometry
ChIP-seq
RNA-seq

Software Mentioned

MACS2
CODEX
UROPA
Ensembl Regulatory Build Oracle
GENCODE
R
R package LOLA
LOLAExt
Enrichr
R package LIMMA - voom

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