PMID: 1200164Nov 1, 1975Paper

Circadian rhythm of biliary excretion and its control mechanisms in rats with chronic biliary drainage

The American Journal of Physiology
K J Ho, J L Drummond

Abstract

Rats with chronic biliary drainage under a rigid lighting schedule (light on at 6 A.M. and off at 6 P.M.) exhibited a remarkable circadian rhythm of bile flow, biliary concentrations and excretory rates of bile salts, cholesterol, and phospholipid. The peak was attained at midnight and nadir at noon except for the peak concentrations of cholesterol and phospholipid occurring at 8 P.M. Cholesterol feeding abolished the circadian rhythm of biliary cholesterol and phospholipid concentrations but not their excretory rates because the daily fluctuation of the bile flow remained unchanged. Bilateral vagotomy enhanced the bile flow rate and shifted the peak of circadian rhythm of all parameters except bile salt 4 h earlier. Bilateral adrenalectomy abolished the circadian variation of the concentration of cholesterol and phospholipid and minimized that of bile salt, but the daily fluctuation of their excretory rates persisted in a lower amplitude. The studies suggested that such circadian rhythm might be controlled simultaneously by multiple factors and could not be entirely abolished by any single special treatment.

Citations

Jan 5, 2011·Expert Opinion on Drug Metabolism & Toxicology·Frédéric Gachon, Dmitri Firsov
Dec 1, 1978·The American Journal of Digestive Diseases·H Y MokS M Grundy
Feb 3, 2009·The Journal of Toxicological Sciences·Hiroshi KawaiAtsushi Mitsumoto
Feb 28, 2014·Journal of Pharmacological Sciences·Yu Tahara, Shigenobu Shibata
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·M RebueltoM Rubio
May 1, 1979·Lipids·C Lutton, E Brot-Laroche
Jun 15, 1978·Experientia·L MerleC Balabaud
Nov 1, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·K NevasaariN T Kärki
Jun 15, 1997·Transplantation·F K Chan, E A Shaffer
Apr 12, 2012·Chronobiology International·Alper OkyarHilde Spahn-Langguth
Jan 1, 1987·European Journal of Drug Metabolism and Pharmacokinetics·J GonzálezA Esteller
Dec 5, 1980·Biochimica Et Biophysica Acta·R B KirkpatrickP G Killenberg
Feb 15, 1982·Biochimica Et Biophysica Acta·C Duléry, D Reisser
Aug 20, 1991·Biochimica Et Biophysica Acta·M J MartinezB Ochoa
Mar 1, 1996·Journal of Pharmaceutical Sciences·R L Pardue, C A White
Jul 1, 1976·Current Problems in Surgery·E A Shaffer, D M Small
Jun 1, 1992·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·B GlasbrennerP Malfertheiner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.