PMID: 9533401Apr 9, 1998Paper

Circadian rhythm of brain-derived neurotrophic factor in the rat suprachiasmatic nucleus

Neuroscience Letters
F Q LiangD J Earnest

Abstract

This study was conducted to determine whether the rat suprachiasmatic nucleus (SCN) is characterized by circadian expression of brain-derived neurotrophic factor (BDNF). In constant darkness, SCN content of both BDNF mRNA and protein oscillated in a circadian fashion. BDNF mRNA and protein levels in the SCN reached peak values during the early subjective day and during the subjective night, respectively. In contrast, the hippocampus showed no sign of circadian rhythmicity in its expression of BDNF mRNA and protein. Since BDNF enhances synaptic transmission in other brain regions, the coincidence between peak expression of BDNF protein in the SCN and the known interval of circadian pacemaker sensitivity to the phase-shifting effects of light may have some implications for the role of BDNF in the circadian regulation of the SCN pacemaker by photic signals from the retinohypothalamic tract.

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Citations

Sep 1, 2000·Brain Research. Brain Research Reviews·K E van EsseveldtG J Boer
Jul 17, 1999·Brain Research. Molecular Brain Research·N C BerchtoldC W Cotman
Feb 25, 2000·Brain Research. Molecular Brain Research·M J SchaafE Vreugdenhil
Oct 11, 2011·Biologie aujourd'hui·Clémence Girardet, Olivier Bosler
May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Pradoldej SompolKeqiang Ye
Jun 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bernat Baeza-RajaKaterina Akassoglou
Jul 27, 2014·Brain Research·Carmel A Martin-Fairey, Antonio A Nunez
Jan 14, 2016·Annals of Medicine·Karen SchmittAnne Eckert
Jan 8, 2016·Current Hypertension Reports·Alexandre PersuMichel Azizi
Jul 3, 2007·Ageing Research Reviews·Fernando Gomez-Pinilla
Apr 26, 2006·Alcoholism, Clinical and Experimental Research·Hiromi Sakata-HagaJennifer D Thomas
May 24, 2003·Brain Research·Yasukazu NakahataKatsuya Nagai
Dec 4, 2003·Brain Research·Claudia DolciFranca Carandente
Aug 6, 2015·Psychopharmacology·Giandomenico SchienaArmando D'Agostino
Oct 7, 2014·Frontiers in Systems Neuroscience·Rajashekar IyerMartha U Gillette
Sep 7, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ritsuko Katoh-SembaAtsuo Nakayama
Sep 27, 2016·Hearing Research·Vasiliki BasinouBarbara Canlon
Oct 25, 2016·Brain Research·Cinthia D Coria-LuceroLorena S Navigatore-Fonzo
Jun 28, 2011·Neurorehabilitation and Neural Repair·Crystal L MacLellanDale Corbett
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matthew J GerdinMargarita L Dubocovich

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