PMID: 11318826Apr 25, 2001Paper

Circadian rhythm of core body temperature in subjects with chronic fatigue syndrome

Clinical Physiology
D L HamilosJ F Jones

Abstract

The pathophysiological basis for chronic fatigue syndrome (CFS) remains poorly understood. Certain symptoms of CFS, namely fatigue, neurocognitive symptoms and sleep disturbance, are similar to those of acute jet lag and shift work syndromes thus raising the possibility that CFS might be a condition associated with disturbances in endogenous circadian rhythms. In this study, we tested this hypothesis by examining the circadian rhythm of core body temperature (CBT) in CFS and control subjects. Continuous recordings of CBT were obtained every 5 min over 48 h in a group of 10 subjects who met the Center for Disease Control (CDC) definition of CFS and 10 normal control subjects. Subjects in the two groups were age, sex and weight-matched and were known to have normal basal metabolic rates and thyroid function. CBT recordings were performed under ambulatory conditions in a clinical research centre with the use of an ingestible radio frequency transmitter pill and a belt-worn receiver-logger. CBT time series were analysed by a cosinor analysis and by a harmonic-regression-plus-correlated-noise model to estimate the mean, amplitude and phase angle of the rhythm. The goodness of fit of each model was also compared using the Akaike Info...Continue Reading

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Citations

Dec 1, 2003·Acta Neuropsychiatrica·A J Cleare
Oct 1, 2015·The Journal of Physiological Sciences : JPS·Masaaki TanakaYasuyoshi Watanabe
May 25, 2005·Psychosomatic Medicine·Annabella Di GiorgioAnthony J Cleare
Apr 18, 2003·Endocrine Reviews·Anthony J Cleare
May 3, 2011·Sleep·Khairunnessa RahmanUte Vollmer-Conna

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