Circadian rhythm of CSF monoamines and hypocretin-1 in restless legs syndrome and Parkinson's disease

Sleep Medicine
J Steven PocetaDaniel F Kripke

Abstract

The symptoms of restless legs syndrome (RLS) have a circadian pattern and central nervous system dopamine has been implicated in the pathogenesis of the condition. We sought to characterize circadian variation in dopamine and related compounds in human cerebro-spinal fluid (CSF). CSF was continuously withdrawn for 22 h from an implanted lumbar intradural catheter and sampled from three patients with RLS, three patients with Parkinson's disease (PD) and three healthy volunteers. Patients had moderate disease severity and took no medications. We assayed CSF dopamine (DA), homovanillic acid (HVA), dihydroxy-phenylacetic acid (DOPAC) and 5-hydroxyindole acetic acid (5-HIAA) from samples every 30 min by reversed-phase HPLC coupled with electrochemical detection. We also measured CSF levels of hypocretin-1 every hour by RIA. The procedure was well-tolerated. One patient ended the study early due to lumbar radicular pain and was not included in the analysis. There were no changes in CSF cell counts or protein levels from the first to the last samples. There was no difference in any of the compounds between groups, so we fit 24-h cosines to examine if the entire group had significant phase consistency. There was a peak for dopamine at ...Continue Reading

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Citations

Feb 13, 2013·Multiple Sclerosis International·Serafeim Katsavos, Maria Anagnostouli
Sep 15, 2009·Journal of Circadian Rhythms·Akbar SharifianAli Fardi
Sep 8, 2010·Sleep Medicine·William G Ondo, Judy J Jia
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Oct 12, 2010·Synapse·Leonardo Rodríguez-SosaGonzalo Flores
Jul 22, 2014·Medicinal Research Reviews·Quanhui ChenDong Gao
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May 9, 2013·Current Opinion in Pediatrics·Demitri F Papolos, Alissa Bronsteen
Mar 29, 2018·Medicines·Konstantinos AssimakopoulosEvangelia Eirini Tsermpini

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