Circadian rhythm of drinking and running-wheel activity in rats with 6-hydroxydopamine lesions of the ventral tegmental area

Brain Research
Y Isobe, H Nishino

Abstract

Circadian rhythms in drinking and running-wheel (locomotor) activity of rats with 6-hydroxydopamine (6-OHDA, 4 microg/2 microl per rat)-induced lesions in the ventral tegmental area (VTA) were examined under a light-dark (LD) cycle and constant dim light (5 lux). Under the LD cycle, the length of the locomotor activity period was decreased during the dark, and increased during the light period in the lesioned rats. Under the constant dim light conditions, the free-running circadian period (tau) of drinking and activity rhythm was longer in lesioned rats than in sham-operated controls. The elongation of the circadian period was accompanied by decrements in activity. These observations suggest that the mesolimbic dopaminergic system modulates rhythms in circadian drinking and locomotor activity.

References

Mar 1, 1990·Brain Research Bulletin·Y IshidaH Nishino
Sep 1, 1988·Acta Physiologica Scandinavica·J GrenhoffT H Svensson
Oct 1, 1973·Journal of Comparative and Physiological Psychology·J AschoffE Pöppel
Nov 1, 1981·Behavioural Brain Research·G F KoobM Le Moal
Dec 24, 1997·Brain Research. Brain Research Reviews·R C Pierce, P W Kalivas

❮ Previous
Next ❯

Citations

Jan 25, 2006·Experimental Brain Research·Paul Christian BaierClaudia Trenkwalder
Nov 12, 2014·Nature Reviews. Neurology·Aleksandar VidenovicSebastiaan Overeem
Jul 1, 2008·Drug and Alcohol Dependence·Mark A SmithMartina L Mustroph
Jul 23, 2011·The European Journal of Neuroscience·Matthew J PaulWilliam J Schwartz
Nov 5, 2005·Alcoholism, Clinical and Experimental Research·Gregg C AllenDavid J Earnest
Oct 5, 2014·Neuroscience·J Mendoza, E Challet
Dec 12, 2003·Journal of Biological Rhythms·Pawel KotejaTheodore Garland
Jan 23, 2020·Acta Physiologica·Kimberly BegemannHenrik Oster
Dec 20, 2018·International Journal of Molecular Sciences·Federica De LazzariFederica Sandrelli
Jul 14, 2020·Frontiers in Neuroscience·Anna Ashton, Aarti Jagannath
Feb 6, 2007·Sleep Medicine Reviews·Jaime M Monti, Daniel Monti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.