Circadian rhythm of gastric acid secretion in men with active duodenal ulcer

Digestive Diseases and Sciences
J G Moore, F Halberg

Abstract

Twenty-one men with active duodenal ulcer underwent hourly gastric acid and 4-hourly plasma collections under fasting conditions. A statistically significant circadian rhythm was demonstrated for the group by population-mean cosinor analysis, a statistical technique designed for time-dependent measurements, for the 24-hr acid secretory output but not for plasma gastrin concentration. These findings are compatible with the interpretation that the circadian rhythm of unstimulated gastric acid secretion, here observed in most patients of the active ulcer group and previously reported for a group of healthy subjects, does not depend critically upon a circadian-rhythm change in plasma gastrin. Chronobiologic statistical techniques add an important quantitative element to the time-dependent measurement of gastrointestinal function of which one example is gastric acidity, with high rates occurring during the evening and low ones in early morning.

References

May 1, 1975·Physiology & Behavior·G B Glavin, A A Mikhail
Nov 1, 1979·The Journal of Nutrition·S FuruyaN R Stevenson
Mar 1, 1976·The American Journal of Physiology·N R Stevenson, J S Fierstein
Jan 1, 1974·Digestion·J G Moore, M Wolfe
Jun 1, 1970·The British Journal of Venereal Diseases·O P AryaR Blowers
Jun 27, 1970·Nature·J G Moore, E Englert
Dec 1, 1983·The American Journal of Anatomy·F Halberg

❮ Previous
Next ❯

Citations

Sep 1, 1992·Journal of Clinical Pharmacology·S OhdoN Ogawa
Dec 1, 1994·Journal of Clinical Pharmacology·G W AmsdenJ J Schentag
Nov 1, 1991·Digestive Diseases and Sciences·K R LarsenM T Dayton
Aug 1, 1993·Digestive Diseases and Sciences·K R LarsenZ Yu
Apr 1, 1994·Digestive Diseases and Sciences·K R LarsenJ G Moore
Jan 1, 1992·Pharmacology & Therapeutics·S W Sanders, J G Moore
Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·V SavarinoG Celle
Mar 1, 1993·Baillière's Clinical Gastroenterology·R E Pounder, A G Fraser
Jun 1, 1996·Journal of Gastroenterology and Hepatology·M J Collen, J D Abdulian
Jan 1, 1991·Annals of the New York Academy of Sciences·J G Moore
Aug 1, 1989·Gut·P DurouxA L Blum
Mar 1, 1990·Gut·V SavarinoG Celle
Jan 11, 2007·Annual Review of Pharmacology and Toxicology·Francis Levi, Ueli Schibler
Jan 11, 2003·Journal of Clinical Pharmacology·Robert A BlumFranklin K Johnson
Mar 28, 2001·Journal of Clinical Pharmacology·T A PuchalskiW J Jusko
Sep 1, 1992·Digestive Diseases and Sciences·K LakhooS Hunter
Aug 10, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Asim Sattwa MandalKetousetuo Kuotsu
Feb 18, 2010·Sleep Medicine Clinics·Mikhail LitinskiSteven A Shea
Aug 1, 1995·Disease-a-month : DM·M Kraft, R J Martin
Jan 5, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·T SaitohT Watanabe
Jan 1, 1992·American Journal of Surgery·J G MooreM T Dayton
Jan 28, 2014·Journal of Clinical Nursing·Annabel MathesonJo-Anne Reid
Feb 1, 1993·Chronobiology International·K R LarsenM T Dayton
Oct 8, 1999·Chronobiology International·S M Harding
Jul 1, 1994·Scandinavian Journal of Gastroenterology·O DöndericiE Eskioğlu
Feb 1, 1991·Chronobiology International·C WhiteJ G Moore
Jan 1, 1991·Alimentary Pharmacology & Therapeutics·R E Pounder
Oct 1, 1990·Alimentary Pharmacology & Therapeutics·S Lanzon-MillerJ R Wood
Jan 1, 1992·Scandinavian Journal of Gastroenterology·E J Boyd, K G Wormsley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.