PMID: 8959371Jan 1, 1996Paper

Circadian rhythms and cancer chemotherapy

Critical Reviews in Eukaryotic Gene Expression
P A Wood, W J Hrushesky

Abstract

Temporal coordination of biologic processes with an approximately 24-h cycle (circadian) is common throughout the animal and plant kingdom and even in some prokaryotic organisms. In all organisms studied, the capability to keep biologic time is an inherited characteristic located intracellularly. These biological clocks anticipate and get the organism ready for regular environmental changes. This indicates both the ubiquity and the weight of the selective environmental pressure to keep time accurately. Several molecular strategies for biologic time keeping have apparently arisen independently several times throughout evolution. The anatomic, biochemical, and molecular mechanisms of the clock are in the process of being defined. This temporal organization at the cellular, organ, and organismic levels results in predictable differences in the capacity of plants, animals, and human beings to respond to therapeutic interventions administered at different times throughout important biologic cycles (e.g., circadian timed therapy). In the treatment of the cancer bearing host, circadian timing of surgery, anticancer drugs, radiation therapy, and biologic agents can result in improved toxicity profiles, enhanced tumor control, and impro...Continue Reading

Citations

Aug 17, 2000·The Anatomical Record·E R Burns
Oct 31, 2000·International Journal of Cancer. Journal International Du Cancer·D W LincolnP A Wood
Aug 25, 2007·Current Treatment Options in Neurology·Lavinia Fiorentino, Sonia Ancoli-Israel
May 4, 2005·Breast Cancer Research and Treatment·Shaojin YouWilliam J M Hrushesky
Jul 25, 2008·Breast Cancer Research and Treatment·Xiaoming YangWilliam J M Hrushesky
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·W J Hrushesky
Jan 25, 2002·European Journal of Cancer Care·S Ancoli-IsraelV Jones
May 9, 2006·Skin Pharmacology and Physiology·A Mehling, J W Fluhr
Nov 9, 2006·Journal of Circadian Rhythms·Naser B Elkum, James D Myles
Dec 23, 2009·Journal of Pineal Research·Brittney Jung-HynesNihal Ahmad
Aug 18, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bi-Botti C Youan
Jun 24, 2008·Contemporary Clinical Trials·Naser B ElkumPranesh Kumar
Oct 17, 1998·Journal of the National Cancer Institute·W J HrusheskyE Haus
Oct 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Holly H GallionUNKNOWN Gynecologic Oncology Group Study
May 2, 2003·Nature Reviews. Cancer·Loning Fu, Cheng Chi Lee
Apr 6, 2006·Cancer Causes & Control : CCC·Maximilian MoserRichard G Stevens
Dec 14, 2007·Chronobiology International·Achraf KhedhaierNaceur A Boughattas
May 12, 1998·The American Journal of Physiology·L A Scheving, W Gardner

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