Circadian rhythms and influencing factors of xerostomia among Parkinson's disease patients

Oral Diseases
Anna Greta BarbeMichael Johannes Noack

Abstract

Parkinson's disease (PD) patients suffer from xerostomia, but limited information exists regarding associations with dysphagia, drooling, daily habits, PD characteristics, or possible circadian rhythms. A questionnaire was administered, including (a) clinical characteristics (comorbidities, prescribed medications, levodopa equivalent daily dose [LEDD], disease duration); (b) self-assessment of dysphagia, xerostomia, drooling (10-cm visual analogue scale [VAS]); (c) 24-hr diary of motor impairment, dyskinesia, xerostomia, dysphagia, drooling, daily habits. Of 75 PD patients who completed the study, 67% reported dysphagia (mean ± standard deviation VAS 4 ± 2), 76% drooling (5 ± 2), 77% xerostomia (5 ± 2). Xerostomia was associated with comorbidities (p = 0.021) and smoking (p = 0.010) and affected by tremor (p = 0.003), dyskinesia (p = 0.010), dysphagia (p < 0.001), food intake (p = 0.005), sleep (p = 0.011), age (p = 0.018), medication intake (p = 0.063), LEDD (p = 0.052), daytime (p = 0.075), disease duration (p = 0.004). Xerostomia peaked at 9 a.m. and 9 p.m. PD patients suffer from xerostomia, dysphagia, and drooling. Subjective dysphagia is associated with drooling and xerostomia, but drooling prevalence or intensity does no...Continue Reading

References

Jan 1, 1976·Clinical Pharmacokinetics·J R Bianchine, G M Shaw
Apr 1, 1990·Controlled Clinical Trials·W D Dupont, W D Plummer
Mar 1, 1970·The Journal of Pharmacy and Pharmacology·M Henning, A Rubenson
Jul 1, 1973·The Journal of Clinical Endocrinology and Metabolism·R B MimsJ E Bethune
Feb 1, 1972·The Journal of Physiology·C Dawes
Dec 27, 1971·JAMA : the Journal of the American Medical Association·L I Goldberg, T L Whitsett
Jan 29, 1981·European Journal of Pharmacology·J H PazoJ H Medina
Jun 1, 1993·Community Dentistry and Oral Epidemiology·D Locker
Jul 1, 1995·Gerodontology·D Locker
Aug 17, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·A SchragN Quinn
Jun 3, 2004·Lancet·Ali SamiiBruce R Ransom
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Melisa ProulxMichel Panisset
Jan 19, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Omar R TumilasciJorge H Pazo
Jul 10, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Piet DirixWalter Van den Bogaert
Sep 26, 2007·Parkinsonism & Related Disorders·Ana Caline NóbregaAilton Melo
Jun 16, 2010·Community Dentistry and Oral Epidemiology·Dorte SmidtAnne Marie Lynge Pedersen
Oct 5, 2010·Progress in Brain Research·K Ray Chaudhuri, Per Odin
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Apr 13, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Johanna G KalfMachiel J Zwarts
Jul 2, 2011·The Journal of the American Dental Association·Alessandro VillaSilvio Abati
Dec 14, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Alastair J NoyceAndrew J Lees
Jul 31, 2013·Parkinsonism & Related Disorders·Sara PietracupaAlfredo Berardelli
Jan 1, 2011·Journal of Parkinson's Disease·Maria G CersosimoEduardo E Benarroch
Aug 22, 2013·The British Journal of Oral & Maxillofacial Surgery·Katherine S GeorgeHelen Witherow
May 28, 2014·Monographs in Oral Science·Konstantina DelliArjan Vissink
Sep 10, 2014·Parkinsonism & Related Disorders·Prachaya SrivanitchapoomMark Hallett
Apr 22, 2015·Journal of the Neurological Sciences·Ruwei OuHuifang Shang
May 20, 2015·Lancet Neurology·Alfonso FasanoRonald F Pfeiffer
Sep 28, 2015·Journal of Neural Transmission·Ruxandra Julia VorovenciAngelo Antonini
Apr 5, 2016·Dental Clinics of North America·Michael D Turner
Jun 4, 2016·Journal of Parkinson's Disease·Christiana OssigAlexander Storch
Jan 31, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A C Böhmer, J Schumacher
Nov 14, 2017·JAMA Neurology·E Ray Dorsey, Bastiaan R Bloem

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Citations

Sep 4, 2020·Journal of Neural Transmission·Olivier RascolUNKNOWN COPARK Study Group
Oct 31, 2019·Journal of Rehabilitation and Assistive Technologies Engineering·Roisin McNaneyRichard Walker
May 14, 2021·Parkinson's Disease·George UmemotoYoshio Tsuboi

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